Frizzleds (FZDs) are G protein–coupled receptors (GPCRs) that bind to WNT family ligands.
FZDs signal through multiple effector proteins, including Dishevelled (DVL), which acts as a …

Class F receptors are considered valuable therapeutic targets due to their role in human
disease, but structural changes accompanying receptor activation remain unexplored. …

WNT-Frizzled (FZD) signaling plays a critical role in embryonic development, stem cell
regulation and tissue homeostasis. FZDs are linked to severe human pathology and are seen as …

Dear Editor, The ten mammalian Frizzleds (FZD1–10) belong to the class F of G protein-coupled
receptors (GPCRs) and mediate WNT signaling through interaction with transducer …

The WNT signaling system governs critical processes during embryonic development and
tissue homeostasis, and its dysfunction can lead to cancer. Details concerning selectivity and …

The class Frizzled of G protein-coupled receptors (GPCRs), consisting of ten Frizzled (FZD 1-10
) subtypes and Smoothened (SMO), remains one of the most enigmatic GPCR families. …

The network of Wingless/Int-1 (WNT)-induced signaling pathways includes β-catenin–dependent
and –independent pathways. β-Catenin regulates T cell factor/lymphoid enhancer–…

Smoothened (SMO) is a GPCR that mediates hedgehog signaling. Hedgehog binds the
transmembrane protein Patched, which in turn regulates SMO activation. Overactive SMO …

Exaggerated Wingless/Int1 (WNT)/Frizzled (FZD) signaling contributes to pathologies
including fibrosis and different forms of cancers. Thus, targeting FZDs as WNT receptors for …

Frizzleds (FZD 1-10 ) are G protein-coupled receptors containing an extracellular cysteine-rich-domain
(CRD) that presents the orthosteric binding site of the 19 mammalian WNTs, the …