User profiles for Carla Bosia
 | Carla Bosiaresearcher, Politecnico di Torino e IIGM Verified email at polito.it Cited by 1395 |
[HTML][HTML] Modelling competing endogenous RNA networks
MicroRNAs (miRNAs) are small RNA molecules, about 22 nucleotide long, which post-transcriptionally
regulate their target messenger RNAs (mRNAs). They accomplish key roles in …
regulate their target messenger RNAs (mRNAs). They accomplish key roles in …
[HTML][HTML] RNAs competing for microRNAs mutually influence their fluctuations in a highly non-linear microRNA-dependent manner in single cells
Background Distinct RNA species may compete for binding to microRNAs (miRNAs). This
competition creates an indirect interaction between miRNA targets, which behave as miRNA …
competition creates an indirect interaction between miRNA targets, which behave as miRNA …
Kinetic modelling of competition and depletion of shared miRNAs by competing endogenous RNAs
Non-coding RNAs play a key role in the post-transcriptional regulation of mRNA translation
and turnover in eukaryotes. miRNAs, in particular, interact with their target RNAs through …
and turnover in eukaryotes. miRNAs, in particular, interact with their target RNAs through …
[HTML][HTML] Stochastic sequestration dynamics: a minimal model with extrinsic noise for bimodal distributions and competitors correlation
Many biological processes are known to be based on molecular sequestration. This kind of
dynamics involves two types of molecular species, namely targets and sequestrants, that …
dynamics involves two types of molecular species, namely targets and sequestrants, that …
[HTML][HTML] The role of incoherent microRNA-mediated feedforward loops in noise buffering
MicroRNAs are endogenous non-coding RNAs which negatively regulate the expression of
protein-coding genes in plants and animals. They are known to play an important role in …
protein-coding genes in plants and animals. They are known to play an important role in …
Integrated transcriptional and competitive endogenous RNA networks are cross-regulated in permissive molecular environments
Competitive endogenous (ce)RNAs cross-regulate each other through sequestration of
shared microRNAs and form complex regulatory networks based on their microRNA signature. …
shared microRNAs and form complex regulatory networks based on their microRNA signature. …
[HTML][HTML] Somatic mutagenesis in satellite cells associates with human skeletal muscle aging
…, M Larsson, G Revêchon, C Bosia… - Nature …, 2018 - nature.com
Human aging is associated with a decline in skeletal muscle (SkM) function and a reduction
in the number and activity of satellite cells (SCs), the resident stem cells. To study the …
in the number and activity of satellite cells (SCs), the resident stem cells. To study the …
Rab11 activity and PtdIns(3)P turnover removes recycling cargo from endosomes
Directional transport of recycling cargo from early endosomes (EE) to the endocytic recycling
compartment (ERC) relies on phosphatidylinositol 3-phosphate (PtdIns(3)P) hydrolysis and …
compartment (ERC) relies on phosphatidylinositol 3-phosphate (PtdIns(3)P) hydrolysis and …
MIRELLA: a mathematical model explains the effect of microRNA-mediated synthetic genes regulation on intracellular resource allocation
Competition for intracellular resources, also known as gene expression burden, induces
coupling between independently co-expressed genes, a detrimental effect on predictability and …
coupling between independently co-expressed genes, a detrimental effect on predictability and …
[HTML][HTML] Gene autoregulation via intronic microRNAs and its functions
Background MicroRNAs, post-transcriptional repressors of gene expression, play a pivotal
role in gene regulatory networks. They are involved in core cellular processes and their …
role in gene regulatory networks. They are involved in core cellular processes and their …