Modelling Myc inhibition as a cancer therapy
Myc is a pleiotropic basic helix–loop–helix leucine zipper transcription factor that coordinates
expression of the diverse intracellular and extracellular programs that together are …
expression of the diverse intracellular and extracellular programs that together are …
[HTML][HTML] Modeling the therapeutic efficacy of p53 restoration in tumors
CP Martins, L Brown-Swigart, GI Evan - Cell, 2006 - cell.com
Although restoration of p53 function is an attractive tumor-specific therapeutic strategy, it
remains unclear whether p53 loss is required only for transition through early bottlenecks in …
remains unclear whether p53 loss is required only for transition through early bottlenecks in …
[HTML][HTML] Cancer-associated fibroblasts induce antigen-specific deletion of CD8+ T Cells to protect tumour cells
Tumours have developed strategies to interfere with most steps required for anti-tumour
immune responses. Although many populations contribute to anti-tumour responses, tumour-…
immune responses. Although many populations contribute to anti-tumour responses, tumour-…
Mutant Kras copy number defines metabolic reprogramming and therapeutic susceptibilities
The RAS/MAPK (mitogen-activated protein kinase) signalling pathway is frequently deregulated
in non-small-cell lung cancer, often through KRAS activating mutations 1 , 2 , 3 . A single …
in non-small-cell lung cancer, often through KRAS activating mutations 1 , 2 , 3 . A single …
Selective activation of p53-mediated tumour suppression in high-grade tumours
Non-small cell lung carcinoma (NSCLC) is the leading cause of cancer-related death worldwide,
with an overall 5-year survival rate of only 10–15% 1 . Deregulation of the Ras pathway …
with an overall 5-year survival rate of only 10–15% 1 . Deregulation of the Ras pathway …
Galacto‐conjugation of Navitoclax as an efficient strategy to increase senolytic specificity and reduce platelet toxicity
…, F Sancenón, M Rovira, L Fruk, CP Martins… - Aging cell, 2020 - Wiley Online Library
Pharmacologically active compounds with preferential cytotoxic activity for senescent cells,
known as senolytics, can ameliorate or even revert pathological manifestations of …
known as senolytics, can ameliorate or even revert pathological manifestations of …
[HTML][HTML] Stromal-driven and Amyloid β-dependent induction of neutrophil extracellular traps modulates tumor growth
…, T Janowitz, M Hoffmann, M Euler, CP Martins… - Nature …, 2021 - nature.com
Tumors consist of cancer cells and a network of non-cancerous stroma. Cancer-associated
fibroblasts (CAF) are known to support tumorigenesis, and are emerging as immune …
fibroblasts (CAF) are known to support tumorigenesis, and are emerging as immune …
The ERBB network facilitates KRAS-driven lung tumorigenesis
…, C Dick, KH Vousden, CP Martins… - Science translational …, 2018 - science.org
KRAS is the most frequently mutated driver oncogene in human adenocarcinoma of the lung.
There are presently no clinically proven strategies for treatment of KRAS-driven lung cancer…
There are presently no clinically proven strategies for treatment of KRAS-driven lung cancer…
Metabolic rewiring in mutant Kras lung cancer
EM Kerr, CP Martins - The FEBS journal, 2018 - Wiley Online Library
Lung cancer is the leading cause of cancer‐related death worldwide, reflecting an unfortunate
combination of very high prevalence and low survival rates, as most cases are diagnosed …
combination of very high prevalence and low survival rates, as most cases are diagnosed …
[HTML][HTML] Development of an ObLiGaRe Doxycycline Inducible Cas9 system for pre-clinical cancer drug discovery
…, EJ Davies, E Hardaker, CP Martins… - Nature …, 2020 - nature.com
The CRISPR-Cas9 system has increased the speed and precision of genetic editing in cells
and animals. However, model generation for drug development is still expensive and time-…
and animals. However, model generation for drug development is still expensive and time-…