The use of omic modalities to dissect the molecular underpinnings of common diseases and
traits is becoming increasingly common. But multi-omic traits can be genetically predicted, …

Background Metabolomics is the comprehensive study of a multitude of small molecules to
gain insight into an organism's metabolism. The research field is dynamic and expanding …

Understanding how genetic variants influence disease risk and complex traits (variant-to-function)
is one of the major challenges in human genetics. Here we present a model-driven …

In recent years, the central role of cell bioenergetics in regulating immune cell function and
fate has been recognized, giving rise to the interest in immunometabolism, an area of …

It has been recently suggested that a significant fraction of homomer protein–protein interfaces
evolve neutrally, without contributing to function, due to a hydrophobic bias in missense …

Altered metabolism is a hallmark of cancer, but little is still known about its regulation. In this
study, we measure transcriptomic, proteomic, phospho-proteomic and fluxomics data in a …

Background Immune check-point blockade (ICB) has shown clinical benefit in mismatch
repair-deficient/microsatellite instability high metastatic colorectal cancer (mCRC) but not in …

Motivation Developing a robust and performant data analysis workflow that integrates all
necessary components whilst still being able to scale over multiple compute nodes is a …

Simple Summary Immune and cancer cells compete for nutrients within the tumor
microenvironment, leading to a metabolic battle between these cell populations. In this battle, tumor …

Simple Summary In this work, we studied the metabolic reprogramming of same-patient-derived
cell lines with increasing metastatic potential to develop new therapeutic approaches …