INTRODUCTION Genetic interactions occur when mutations in two or more genes combine
to generate an unexpected phenotype. An extreme negative or synthetic lethal genetic …

Global insights into cellular organization and genome function require comprehensive
understanding of the interactome networks that mediate genotype–phenotype relationships 1 , 2 . …

pyDockWEB is a web server for the rigid-body docking prediction of protein–protein complex
structures using a new version of the pyDock scoring algorithm. We use here a new custom …

INTRODUCTION Genetic interactions occur when mutations in different genes combine to
result in a phenotype that is different from expectation based on those of the individual …

INTRODUCTION Genetic suppression occurs when the phenotypic defects caused by a
mutated gene are rescued by a mutation in another gene. These genetic interactions can …

Understanding the mechanisms of coronavirus disease 2019 (COVID-19) disease severity
to efficiently design therapies for emerging virus variants remains an urgent challenge of the …

Motivation: Prediction of protein–protein complexes from the coordinates of their unbound
components usually starts by generating many potential predictions from a rigid-body 6D …

Although we now routinely sequence human genomes, we can confidently identify only a
fraction of the sequence variants that have a functional impact. Here, we developed a deep …

The CAPRI (Critical Assessment of Predicted Interactions) and CASP (Critical Assessment
of protein Structure Prediction) experiments have demonstrated the power of community-wide …

BACKGROUND & AIMS: Secondary bacterial peritonitis in cirrhotic patients is an
uncommon entity that has been little reported. Our aim is to analyse the frequency, clinical …