User profiles for Carlos Cruchaga
Carlos CruchagaProfessor. NeuroGenomics and Informatics Center Director Verified email at wustl.edu Cited by 45023 |
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
…, C Baldwin, T Becker, V Gudnason, C Cruchaga… - Nature …, 2013 - nature.com
Eleven susceptibility loci for late-onset Alzheimer's disease (LOAD) were identified by previous
studies; however, a large portion of the genetic risk for this disease remains unexplained. …
studies; however, a large portion of the genetic risk for this disease remains unexplained. …
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease
We undertook a two-stage genome-wide association study (GWAS) of Alzheimer's disease (AD)
involving over 16,000 individuals, the most powerful AD GWAS to date. In stage 1 (3,941 …
involving over 16,000 individuals, the most powerful AD GWAS to date. In stage 1 (3,941 …
[HTML][HTML] TREM2 Variants in Alzheimer's Disease
…, E Rogaeva, E Majounie, C Cruchaga… - … England Journal of …, 2013 - Mass Medical Soc
Background Homozygous loss-of-function mutations in TREM2, encoding the triggering
receptor expressed on myeloid cells 2 protein, have previously been associated with an …
receptor expressed on myeloid cells 2 protein, have previously been associated with an …
Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease
We sought to identify new susceptibility loci for Alzheimer's disease through a staged
association study (GERAD+) and by testing suggestive loci reported by the Alzheimer's Disease …
association study (GERAD+) and by testing suggestive loci reported by the Alzheimer's Disease …
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease
…, N Ertekin-Taner, SG Younkin, C Cruchaga… - Nature …, 2011 - nature.com
The Alzheimer Disease Genetics Consortium (ADGC) performed a genome-wide association
study of late-onset Alzheimer disease using a three-stage design consisting of a discovery …
study of late-onset Alzheimer disease using a three-stage design consisting of a discovery …
Human apoE isoforms differentially regulate brain amyloid-β peptide clearance
…, JC Morris, KG Mawuenyega, C Cruchaga… - Science translational …, 2011 - science.org
The apolipoprotein E (APOE) ε4 allele is the strongest genetic risk factor for late-onset,
sporadic Alzheimer’s disease (AD). The APOE ε4 allele markedly increases AD risk and …
sporadic Alzheimer’s disease (AD). The APOE ε4 allele markedly increases AD risk and …
Analysis of shared heritability in common disorders of the brain
…, JI Rotter, G Ransmayr, BT Hyman, C Cruchaga… - Science, 2018 - science.org
INTRODUCTION Brain disorders may exhibit shared symptoms and substantial epidemiological
comorbidity, inciting debate about their etiologic overlap. However, detailed study of …
comorbidity, inciting debate about their etiologic overlap. However, detailed study of …
Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes
Stroke has multiple etiologies, but the underlying genes and pathways are largely unknown.
We conducted a multiancestry genome-wide-association meta-analysis in 521,612 …
We conducted a multiancestry genome-wide-association meta-analysis in 521,612 …
ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy
…, C Xiong, JL Del-Aguila, JC Morris, C Cruchaga… - Nature, 2017 - nature.com
APOE4 is the strongest genetic risk factor for late-onset Alzheimer disease. ApoE4 increases
brain amyloid-β pathology relative to other ApoE isoforms 1 . However, whether APOE …
brain amyloid-β pathology relative to other ApoE isoforms 1 . However, whether APOE …
[HTML][HTML] Stroke genetics informs drug discovery and risk prediction across ancestries
Previous genome-wide association studies (GWASs) of stroke — the second leading cause
of death worldwide — were conducted predominantly in populations of European ancestry 1 …
of death worldwide — were conducted predominantly in populations of European ancestry 1 …