Analysis of genome-wide association data highlights candidates for drug repositioning in psychiatry
Abstract Knowledge of psychiatric disease genetics has advanced rapidly during the past
decade with the advent of genome-wide association studies (GWAS). However, less progress …
decade with the advent of genome-wide association studies (GWAS). However, less progress …
Causal relationships between blood lipids and depression phenotypes: a Mendelian randomisation analysis
BackgroundThe etiology of depression remains poorly understood. Changes in blood lipid
levels were reported to be associated with depression and suicide, however study findings …
levels were reported to be associated with depression and suicide, however study findings …
Differential associations of depression‐related phenotypes with cardiometabolic risks: Polygenic analyses and exploring shared genetic variants and pathways
BCF Wong, CKL Chau, FK Ao, CH Mo… - Depression and …, 2019 - Wiley Online Library
Background Numerous studies have suggested associations between depression and
cardiometabolic (CM) diseases. However, little is known about the mechanism underlying this …
cardiometabolic (CM) diseases. However, little is known about the mechanism underlying this …
Translating GWAS findings into therapies for depression and anxiety disorders: gene-set analyses reveal enrichment of psychiatric drug classes and implications for …
BackgroundDepression and anxiety disorders (AD) are the first and sixth leading causes of
disability worldwide. Despite their high prevalence and significant disability resulted, there …
disability worldwide. Despite their high prevalence and significant disability resulted, there …
Exploring causal relationships between COVID-19 and cardiometabolic disorders: a bi-directional Mendelian randomization study
Background More than 100 million cases of COVID-19 have been reported worldwide. A
number of risk factors for infection or severe infection have been identified, however …
number of risk factors for infection or severe infection have been identified, however …
Neuropsychiatric disorders as risk factors and consequences of COVID-19: a Mendelian randomization study
Background More than 180 million cases of COVID-19 have been reported worldwide. It has
been proposed that neuropsychiatric disorders may be risk factors and/or consequences of …
been proposed that neuropsychiatric disorders may be risk factors and/or consequences of …
A framework to decipher the genetic architecture of combinations of complex diseases: applications in cardiovascular medicine
L Yin, CKL Chau, YP Lin, S Rao, Y Xiang… - …, 2021 - academic.oup.com
Motivation Currently, most genome-wide association studies (GWAS) are studies of a single
disease against controls. However, an individual is often affected by more than one condition…
disease against controls. However, an individual is often affected by more than one condition…
Differential associations of various depression-related phenotypes with cardiometabolic risks: Identification of shared genetic factors and implications for drug …
BCF Wong, CKL Chau, FK Ao, CH Mo, SY Wong… - BioRxiv, 2017 - biorxiv.org
Numerous studies have suggested associations between depression and cardiometabolic
abnormalities or diseases, such as coronary artery disease and type 2 diabetes. However, …
abnormalities or diseases, such as coronary artery disease and type 2 diabetes. However, …
Translating GWAS findings into therapies for depression and anxiety disorders: drug repositioning using gene-set analyses reveals enrichment of psychiatric drug …
Depression and anxiety disorders are the first and sixth leading cause of disability
worldwide according to latest reports from the World Health Organization. Despite their high …
worldwide according to latest reports from the World Health Organization. Despite their high …
Exploring repositioning opportunities and side-effects of statins: a Mendelian randomization study of HMG-CoA reductase inhibition with 55 complex traits
SO Hon-Cheong, CK Chau, K Zhao - bioRxiv, 2017 - biorxiv.org
Statin is one of the most commonly prescribed medications worldwide. Besides reduction of
cardiovascular risks, statins have been proposed for the prevention or treatment of other …
cardiovascular risks, statins have been proposed for the prevention or treatment of other …