User profiles for Carlos N Pato
Carlos PatoProfessor, Executive Chair of Psychiatry, Rutgers University Verified email at rutgers.edu Cited by 41518 |
Common polygenic variation contributes to risk of schizophrenia and bipolar disorder
Schizophrenia is a severe mental disorder with a lifetime risk of about 1%, characterized by
hallucinations, delusions and cognitive deficits, with heritability estimated at up to 80% 1 , 2 . …
hallucinations, delusions and cognitive deficits, with heritability estimated at up to 80% 1 , 2 . …
Biological insights from 108 schizophrenia-associated genetic loci
…, GN Papadimitriou, S Papiol, E Parkhomenko, MT Pato… - Nature, 2014 - nature.com
Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of
alleles, including common alleles of small effect that might be detected by genome-wide …
alleles, including common alleles of small effect that might be detected by genome-wide …
Rare coding variants in ten genes confer substantial risk for schizophrenia
Rare coding variation has historically provided the most direct connections between gene
function and disease pathogenesis. By meta-analysing the whole exomes of 24,248 …
function and disease pathogenesis. By meta-analysing the whole exomes of 24,248 …
Assessing the impact of population stratification on genetic association studies
Population stratification refers to differences in allele frequencies between cases and controls
due to systematic differences in ancestry rather than association of genes with disease. It …
due to systematic differences in ancestry rather than association of genes with disease. It …
The PhenX Toolkit: get the most from your measures
The potential for genome-wide association studies to relate phenotypes to specific genetic
variation is greatly increased when data can be combined or compared across multiple …
variation is greatly increased when data can be combined or compared across multiple …
Comorbidity of severe psychotic disorders with measures of substance use
SM Hartz, CN Pato, H Medeiros… - JAMA …, 2014 - jamanetwork.com
Importance Although early mortality in severe psychiatric illness is linked to smoking and
alcohol, to our knowledge, no studies have comprehensively characterized substance use …
alcohol, to our knowledge, no studies have comprehensively characterized substance use …
Genome-wide association study of obsessive-compulsive disorder
Obsessive-compulsive disorder (OCD) is a common, debilitating neuropsychiatric illness
with complex genetic etiology. The International OCD Foundation Genetics Collaborative (…
with complex genetic etiology. The International OCD Foundation Genetics Collaborative (…
[HTML][HTML] Partitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture
The direct estimation of heritability from genome-wide common variant data as implemented
in the program Genome-wide Complex Trait Analysis (GCTA) has provided a means to …
in the program Genome-wide Complex Trait Analysis (GCTA) has provided a means to …
Complement genes contribute sex-biased vulnerability in diverse disorders
…, AA Steixner, E Parkhomenko, MT Pato… - Nature, 2020 - nature.com
Many common illnesses, for reasons that have not been identified, differentially affect men
and women. For instance, the autoimmune diseases systemic lupus erythematosus (SLE) and …
and women. For instance, the autoimmune diseases systemic lupus erythematosus (SLE) and …
Uncovering the hidden risk architecture of the schizophrenias: confirmation in three independent genome-wide association studies
Objective: The authors sought to demonstrate that schizophrenia is a heterogeneous group
of heritable disorders caused by different genotypic networks that cause distinct clinical …
of heritable disorders caused by different genotypic networks that cause distinct clinical …