Clathrin‐mediated endocytosis ( CME ) regulates signaling from the plasma membrane.
Analysis of clathrin‐coated pit ( CCP ) dynamics led us to propose the existence of a rate‐limiting…

The PD-1/PD-L1 pathway is a key immune checkpoint that regulates T cell activation. There
is strong rationale to develop PD-1 agonists as therapeutics against autoimmunity, but …

The use of enzymes to interfere with quorum sensing represents an attractive strategy to
fight bacterial infections. We used PvdQ, an effective quorum-quenching enzyme from …

The redesign of enzymes to produce catalysts for a predefined transformation remains a
major challenge in protein engineering. Here, we describe the structure-based engineering of …

Clathrin-mediated endocytosis (CME) constitutes the major pathway for uptake of signaling
receptors into eukaryotic cells. As such, CME regulates signaling from cell-surface receptors, …

Signaling receptors are internalized and regulated by clathrin-mediated endocytosis (CME).
Two clathrin light chain isoforms, CLCa and CLCb, are integral components of the endocytic …

Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) is a death ligand cytokine
known for its cytotoxic activity against malignantly transformed cells. TRAIL induces cell …

Bacillus subtilis strain 168 produces the extremely stable lantibiotic sublancin 168, which
has a broad spectrum of bactericidal activity. Both sublancin 168 production and producer …

In subcellular light-sheet fluorescence microscopy (LSFM) of adherent cells, glass substrates
are advantageously rotated relative to the excitation and emission light paths to avoid glass…

The iron binding siderophore pyoverdine constitutes a major adaptive factor contributing to
both virulence and survival in fluorescent pseudomonads. For decades, pyoverdine …