To explore the distinct genotypic and phenotypic states of melanoma tumors, we applied
single-cell RNA sequencing (RNA-seq) to 4645 single cells isolated from 19 patients, profiling …

There is pressing urgency to understand the pathogenesis of the severe acute respiratory
syndrome coronavirus clade 2 (SARS-CoV-2), which causes the disease COVID-19. SARS-…

COVID-19, which is caused by SARS-CoV-2, can result in acute respiratory distress syndrome
and multiple organ failure 1 , 2 , 3 – 4 , but little is known about its pathophysiology. Here …

Innate lymphoid cells (ILCs), a heterogeneous cell population, are critical in orchestrating
immunity and inflammation in the intestine, but whether ILCs influence immune responses or …

Innate lymphoid cells (ILCs) are a recently characterized family of immune cells that have
critical roles in cytokine-mediated regulation of intestinal epithelial cell barrier integrity 1 , 2 , 3 , …

Angiotensin-converting enzyme 2 (ACE2) and accessory proteases (TMPRSS2 and CTSL)
are needed for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cellular entry…

SARS-CoV-2 infection can cause severe respiratory COVID-19. However, many individuals
present with isolated upper respiratory symptoms, suggesting potential to constrain viral …

The COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, creates an urgent
need for identifying molecular mechanisms that mediate viral entry, propagation, and tissue …

The development and severity of inflammatory bowel diseases and other chronic inflammatory
conditions can be influenced by host genetic and environmental factors, including signals …

Barrier tissue immune responses are regulated in part by nociceptors. Nociceptor ablation
alters local immune responses at peripheral sites and within draining lymph nodes (LNs). The …