Triggering receptor expressed in myeloid cells (TREM2) is a member of the immunoglobulin
superfamily and is expressed in macrophages, dendritic cells, microglia, and osteoclasts. …

The G2019S mutation in the multidomain protein leucine-rich repeat kinase 2 (LRRK2) is
one of the most frequently identified genetic causes of Parkinson’s disease (PD). Clinically, …

Signaling through innate immune receptors such as the Toll-like receptor (TLR)/interleukin-1
receptor (IL-1R) superfamily proceeds via the assembly of large membrane-proximal …

Myelin-associated glycoprotein (MAG) is a sialic acid binding Ig-like lectin (Siglec) which has
been characterized as potent myelin-derived inhibitor of neurite outgrowth. Two members …

The immunomodulatory drug fingolimod (FTY720, 2-amino-2-[2-(4-octylphenyl) ethyl] propane-1,
3-diol), derived from a fungal metabolite (ISP-1, myriocin), is phosphorylated invivo by …

Retroviral gene delivery systems for RNA polymerase II (RNA pol II)-based promoters have
been developed and are widely used in gene transfer studies. In contrast, gene delivery …

The antiviral activities of intracellularly expressed antisense RNAs complementary to the
human immunodeficiency virus type 1 (HIV-1) pol, vif, and env genes and the 3′ long terminal …

Atopic dermatitis (AD) is a debilitating inflammatory skin disorder. Biologics targeting the IL-4/IL-13
axis are effective in AD, but there is still a large proportion of patients who do not …

Previously, we described two mutants of the cellular Rev co-factor, eukaryotic initiation
factor 5A (eIF-5AM13 and M14), which suppress human immunodeficiency virus type 1 (HIV-1) …

Intracellular expression of antisense transcripts was evaluated for its potential to interfere with
human immunodeficiency virus type 1 (HIV-1) replication. Retroviral vectors encoding HIV-…