Met, metastasis, motility and more
C Birchmeier, W Birchmeier, E Gherardi… - … reviews Molecular cell …, 2003 - nature.com
Hepatocyte growth factor/scatter factor and its receptor, the tyrosine kinase Met, arose late in
evolution and are unique to vertebrates. In spite of this, Met uses molecules such as Gab1 …
evolution and are unique to vertebrates. In spite of this, Met uses molecules such as Gab1 …
Targeting MET in cancer: rationale and progress
E Gherardi, W Birchmeier, C Birchmeier… - Nature reviews …, 2012 - nature.com
Uncontrolled cell survival, growth, angiogenesis and metastasis are essential hallmarks of
cancer. Genetic and biochemical data have demonstrated that the growth and motility factor …
cancer. Genetic and biochemical data have demonstrated that the growth and motility factor …
Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud
…, D Riethmacher, S Isenmann, A Aguzzi, C Birchmeier - Nature, 1995 - nature.com
LIMB muscles develop from cells that migrate from the somites 1,2 . The signal that induces
migration of myogenic precursor cells to the limb emanates from the mesenchyme of the limb …
migration of myogenic precursor cells to the limb emanates from the mesenchyme of the limb …
Multiple essential functions of neuregulin in development
D Meyer, C Birchmeier - Nature, 1995 - nature.com
NEUREGULIN (also called NDF, heregulin, GGF and ARIA) is a member of the EGF family
which induces growth and differentiation of epithelial, glial and muscle cells in culture 1–4 . …
which induces growth and differentiation of epithelial, glial and muscle cells in culture 1–4 . …
[HTML][HTML] A validated regulatory network for Th17 cell specification
…, A Greenfield, Y Yang, P Jain, FK Kirigin, C Birchmeier… - Cell, 2012 - cell.com
Th17 cells have critical roles in mucosal defense and are major contributors to inflammatory
disease. Their differentiation requires the nuclear hormone receptor RORγt working with …
disease. Their differentiation requires the nuclear hormone receptor RORγt working with …
Axonal neuregulin-1 regulates myelin sheath thickness
…, BG Brinkmann, TM Fischer, B Haug, C Birchmeier… - Science, 2004 - science.org
In the nervous system of vertebrates, myelination is essential for rapid and accurate impulse
conduction. Myelin thickness depends on axon fiber size. We use mutant and transgenic …
conduction. Myelin thickness depends on axon fiber size. We use mutant and transgenic …
Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function
…, C Kocks, R Kühn, C Rosenmund, C Birchmeier… - Science, 2017 - science.org
INTRODUCTION Recently, a special class of RNAs has excited researchers and triggered
hundreds of now-published studies. Known as circular RNAs (circRNAs), these RNAs are …
hundreds of now-published studies. Known as circular RNAs (circRNAs), these RNAs are …
The transcription factor Sox10 is a key regulator of peripheral glial development
…, M Rossner, KA Nave, C Birchmeier… - Genes & …, 2001 - genesdev.cshlp.org
The molecular mechanisms that determine glial cell fate in the vertebrate nervous system
have not been elucidated. Peripheral glial cells differentiate from pluripotent neural crest cells. …
have not been elucidated. Peripheral glial cells differentiate from pluripotent neural crest cells. …
MAPKAP kinase 2 is essential for LPS-induced TNF-α biosynthesis
…, A Neininger, C Schubert, R Eckert, C Birchmeier… - Nature cell …, 1999 - nature.com
MAPKAP kinase 2 (MK2) is one of several kinases that are regulated through direct
phosphorylation by p38 MAP kinase. By introducing a targeted mutation into the mouse MK2 gene, …
phosphorylation by p38 MAP kinase. By introducing a targeted mutation into the mouse MK2 gene, …
Control of peripheral nerve myelination by the ß-secretase BACE1
…, A Rittger, B DeStrooper, P Saftig, C Birchmeier… - Science, 2006 - science.org
Although BACE1 (beta-site amyloid precursor protein–cleaving enzyme 1) is essential for the
generation of amyloid-b peptide in Alzheimer's disease, its physiological function is unclear…
generation of amyloid-b peptide in Alzheimer's disease, its physiological function is unclear…