Cryogenic electron microscopy and data processing enable the determination of structures
of isolated macromolecules to near-atomic resolution. However, these data do not provide …

Leucine-rich repeat-containing G-protein coupled receptor 5-positive (Lgr5 + ) stem cells
reside at crypt bottoms of the small and large intestine. Small intestinal Paneth cells supply …

The treatment of Alzheimer's disease and many other brain-related disorders is limited because
of the presence of the blood–brain barrier, which highly regulate the crossing of drugs. …

Outer-inner membrane vesicles (O-IMVs) were recently described as a new type of membrane
vesicle secreted by the Antarctic bacterium Shewanella vesiculosa M7T. Their formation …

The lack of registered drugs for nonalcoholic fatty liver disease (NAFLD) is partly due to the
paucity of human-relevant models for target discovery and compound screening. Here we …

In recent years, cell-penetrating peptides have proven to be an efficient intracellular delivery
system. The mechanism for CPP internalisation, which first involves interaction with the …

Barrier‐to‐autointegration factor (BAF) is an essential, highly conserved, metazoan protein.
BAF interacts with LEM (LAP2, emerin, MAN1) domain‐carrying proteins of the inner nuclear …

Voltage-dependent K + channels (VDPC) are expressed in most mammalian cells and
involved in the proliferation and activation of lymphocytes. However, the role of VDPC in …

Vaccinia virus (VV) has a complex morphogenetic pathway whose first steps are poorly
characterized. We have studied the early phase of VV assembly, when viral factories and …

Amyloids are implicated in neurodegenerative diseases. Fibrillar aggregates of the amyloid-β
protein (Aβ) are the main component of the senile plaques found in brains of Alzheimer’s …