User profiles for Carmen Nussbaum-Krammer
Carmen Nussbaum-KrammerLudwig-Maximilians-University Verified email at med.uni-muenchen.de Cited by 12197 |
[PDF][PDF] Human Hsp70 disaggregase reverses Parkinson's-linked α-synuclein amyloid fibrils
X Gao, M Carroni, C Nussbaum-Krammer, A Mogk… - Molecular cell, 2015 - cell.com
Intracellular amyloid fibrils linked to neurodegenerative disease typically accumulate in an
age-related manner, suggesting inherent cellular capacity for counteracting amyloid formation …
age-related manner, suggesting inherent cellular capacity for counteracting amyloid formation …
Investigating the spreading and toxicity of prion-like proteins using the metazoan model organism C. elegans
CI Nussbaum-Krammer, MF Neto… - JoVE (Journal of …, 2015 - jove.com
Prions are unconventional self-propagating proteinaceous particles, devoid of any coding
nucleic acid. These proteinaceous seeds serve as templates for the conversion and …
nucleic acid. These proteinaceous seeds serve as templates for the conversion and …
[HTML][HTML] Disassembly of Tau fibrils by the human Hsp70 disaggregation machinery generates small seeding-competent species
…, A Mogk, B Bukau, C Nussbaum-Krammer - Journal of Biological …, 2020 - ASBMB
The accumulation of amyloid Tau aggregates is implicated in Alzheimer's disease (AD) and
other tauopathies. Molecular chaperones are known to maintain protein homeostasis. Here, …
other tauopathies. Molecular chaperones are known to maintain protein homeostasis. Here, …
[HTML][HTML] Molecular chaperones: a double-edged sword in neurodegenerative diseases
…, E Nachman, C Nussbaum-Krammer - Frontiers in aging …, 2020 - frontiersin.org
Aberrant accumulation of misfolded proteins into amyloid deposits is a hallmark in many age-related
neurodegenerative diseases, including Alzheimer’s disease (AD), Parkinson’s …
neurodegenerative diseases, including Alzheimer’s disease (AD), Parkinson’s …
The HSP110/HSP70 disaggregation system generates spreading‐competent toxic α‐synuclein species
…, A Mogk, B Bukau, C Nussbaum‐Krammer - The EMBO …, 2020 - embopress.org
The accumulation and prion‐like propagation of α‐synuclein and other amyloidogenic
proteins are associated with devastating neurodegenerative diseases. Metazoan heat shock …
proteins are associated with devastating neurodegenerative diseases. Metazoan heat shock …
Proteotoxic stress and ageing triggers the loss of redox homeostasis across cellular compartments
…, A Minnen, MS Hipp, C Nussbaum‐Krammer… - The EMBO …, 2015 - embopress.org
The cellular proteostasis network integrates the protein folding and clearance machineries in
multiple sub‐cellular compartments of the eukaryotic cell. The endoplasmic reticulum ( ER ) …
multiple sub‐cellular compartments of the eukaryotic cell. The endoplasmic reticulum ( ER ) …
Modulation of amyloid states by molecular chaperones
…, C Nussbaum-Krammer… - Cold Spring Harbor …, 2019 - cshperspectives.cshlp.org
Aberrant protein aggregation is a defining feature of most neurodegenerative diseases.
During pathological aggregation, key proteins transition from their native state to alternative …
During pathological aggregation, key proteins transition from their native state to alternative …
[HTML][HTML] NSs amyloid formation is associated with the virulence of Rift Valley fever virus in mice
…, M Flamand, C Nussbaum-Krammer… - Nature …, 2020 - nature.com
Amyloid fibrils result from the aggregation of host cell-encoded proteins, many giving rise to
specific human illnesses such as Alzheimer’s disease. Here we show that the major …
specific human illnesses such as Alzheimer’s disease. Here we show that the major …
Caenorhabditis elegans as a model system for studying non-cell-autonomous mechanisms in protein-misfolding diseases
CI Nussbaum-Krammer… - Disease models & …, 2014 - journals.biologists.com
Caenorhabditis elegans has a number of distinct advantages that are useful for understanding
the basis for cellular and organismal dysfunction underlying age-associated diseases of …
the basis for cellular and organismal dysfunction underlying age-associated diseases of …
The cytoprotective sequestration activity of small heat shock proteins is evolutionarily conserved
The chaperone-mediated sequestration of misfolded proteins into inclusions is a pivotal
cellular strategy to maintain proteostasis in Saccharomyces cerevisiae, executed by small heat …
cellular strategy to maintain proteostasis in Saccharomyces cerevisiae, executed by small heat …