User profiles for Carol J. Thiele
 | Carol J. ThieleSenior Investigator, National Cancer Institute Verified email at nih.gov Cited by 12300 |
Decreased expression of N-myc precedes retinoic acid-induced morphological differentiation of human neuroblastoma
CJ Thiele, CP Reynolds, MA Israel - Nature, 1985 - nature.com
Proto-oncogenes may be important in the cellular processes central for the growth and
differentiation of normal cells 1,2 . N-myc is a DNA sequence which shares limited homology to …
differentiation of normal cells 1,2 . N-myc is a DNA sequence which shares limited homology to …
Glycogen synthase kinase 3β (GSK3β) mediates 6‐hydroxydopamine‐induced neuronal death
The causes of sporadic Parkinson's disease (PD) are poorly understood. 6‐Hydroxydopamine
(6‐ OHDA), a PD mimetic, is widely used to model this neurodegenerative disorder in vitro …
(6‐ OHDA), a PD mimetic, is widely used to model this neurodegenerative disorder in vitro …
[HTML][HTML] Adrenomedullin expression in human tumor cell lines Its potential role as an autocrine growth factor
MJ Miller, A Martínez, EJ Unsworth, CJ Thiele… - Journal of Biological …, 1996 - ASBMB
Although adrenomedullin (AM) previously has been identified in human tumors, its role has
remained elusive. Analysis by reverse transcriptase-polymerase chain reaction (RT-PCR) …
remained elusive. Analysis by reverse transcriptase-polymerase chain reaction (RT-PCR) …
On Trk—The TrkB Signal Transduction Pathway Is an Increasingly Important Target in Cancer Biology
CJ Thiele, Z Li, AE McKee - Clinical cancer research, 2009 - AACR
In the beginning, Trk was an oncogene. Yet Neurotrophin-Trk signaling came to preeminence
in the field of neurobiology. Now it is appreciated that Trks regulate important processes in …
in the field of neurobiology. Now it is appreciated that Trks regulate important processes in …
MS-27-275, an Inhibitor of Histone Deacetylase, Has Marked in Vitro and in Vivo Antitumor Activity against Pediatric Solid Tumors
The antitumor efficacy of the synthetic benzamide derivative MS-27-275 (MS-275), an
inhibitor of histone deacetylation [T. Suzuki et al., J. Med. Chem., 42: 3001–3003, 1999], was …
inhibitor of histone deacetylation [T. Suzuki et al., J. Med. Chem., 42: 3001–3003, 1999], was …
Repression of the gene encoding the TGF-β type II receptor is a major target of the EWS-FLI1 oncoprotein
…, YH Im, J Chang, SG Choi, PHB Sorensen, CJ Thiele… - Nature …, 1999 - nature.com
Chromosomal translocations resulting in the expression of chimaeric transcription factors
are frequently observed in tumour cells 1, and have been suggested to be a common …
are frequently observed in tumour cells 1, and have been suggested to be a common …
Brain-derived neurotrophic factor activation of TrkB induces vascular endothelial growth factor expression via hypoxia-inducible factor-1α in neuroblastoma cells
…, KC Martin, JK Jackson, K Beppu, CW Woo, CJ Thiele - Cancer research, 2006 - AACR
The extent of angiogenesis and/or vascular endothelial growth factor (VEGF) expression in
neuroblastoma tumors correlates with metastases, N-myc amplification, and poor clinical …
neuroblastoma tumors correlates with metastases, N-myc amplification, and poor clinical …
Expression of Brain-derived Neurotrophic Factor and p145TrkB Affects Survival, Differentiation, and Invasiveness of Human Neuroblastoma Cells
A large number of poor prognosis neuroblastoma (NB) tumors constitutively express brain-derived
neurotrophic factor (BDNF) and variably express the gene for its tyrosine kinase (Trk) …
neurotrophic factor (BDNF) and variably express the gene for its tyrosine kinase (Trk) …
Brain-derived neurotrophic factor activation of TrkB protects neuroblastoma cells from chemotherapy-induced apoptosis via phosphatidylinositol 3′-kinase pathway
Neuroblastoma (NB) tumors expressing high levels of brain-derived neurotrophic factor (BDNF)
and TrkB are associated with poor 5-year survival outcomes. Our previous studies …
and TrkB are associated with poor 5-year survival outcomes. Our previous studies …
The Role of INI1 and the SWI/SNF Complex in the Development of Rhabdoid Tumors: Meeting Summary from the Workshop on Childhood Atypical Teratoid …
…, ES Knudsen, RJ Packer, CWM Roberts, CJ Thiele… - 2002 - AACR
A workshop on childhood atypical teratoid/rhabdoid tumors of the central nervous system,
sponsored by the National Cancer Institute and the Pediatric Brain Tumor Foundation of the …
sponsored by the National Cancer Institute and the Pediatric Brain Tumor Foundation of the …