We have addressed the role of the proneural bHLH genes Neurogenin2 (Ngn2) and Mash1
in the selection of neuronal and glial fates by neural stem cells. We show that mice mutant …

The cellular properties of neural progenitor cells have been best characterized in the
telencephalon, the most complex region of the vertebrate brain. In recent years, several …

Neocortical projection neurons, which segregate into six cortical layers according to their
birthdate, have diverse morphologies, axonal projections and molecular profiles, yet they share …

The neural bHLH genes Mash1 and Ngn2 are expressed in complementary populations of
neural progenitors in the central and peripheral nervous systems. Here, we have …

The generation of neurons by progenitor cells involves the tight coordination of multiple cellular
activities, including cell cycle exit, initiation of neuronal differentiation, and cell migration. …

The molecular mechanisms specifying the dendritic morphology of different neuronal
subtypes are poorly understood. Here we demonstrate that the bHLH transcription factor …

The formation of functional neural circuits in the vertebrate central nervous system (CNS)
requires that appropriate numbers of the correct types of neuronal and glial cells are generated …

We have examined how genetic pathways that specify neuronal identity and regulate
neurogenesis interface in the vertebrate neural tube. Here, we demonstrate that expression of the …

We showed previously that the proneural genes Neurogenin1 (Ngn1) and Ngn2 are required
to specify the phenotypes of early- and not late-born neurons in the neocortex, acting in …

Neural cell fate specification is well understood in the embryonic cerebral cortex, where the
proneural genes Neurog2 and Ascl1 are key cell fate determinants. What is less well …