Following root avulsion, spinal nerves are physically disconnected from the spinal cord.
Severe motoneuron death and inefficient axon regeneration often result in devastating motor …

When spinal roots are torn off from the spinal cord, both the peripheral and central nervous
system get damaged. As the motoneurons lose their axons, they start to die rapidly, whereas …

… Carolin Ruven and Wutian Wu conceived and designed the experiments; Carolin Ruven
performed the experiments, analyzed the data and wrote the paper; Wen Li, Heng Li and Wai-…

Spinal root avulsion is an excellent model for studying the response of motoneurons to severe
injury to their axons (Koliatsos et al., 1994). In this model (‘Avulsion Model’), spinal roots …

Corticospinal neurons (CSN) are centrally required for skilled voluntary movement, which
necessitates that they establish precise subcerebral connectivity with the brainstem and spinal …

Uncovering the intricacies of the recovery trajectory following spinal cord injury (SCI) has
remained a critical exploration for researchers and clinicians, fostering the need of innovative …

The neonatal central nervous system (CNS) in mammals is known to support greater
regeneration than the adult CNS. Established models of neonatal CNS injuries cause significant …

Peripheral nerves are prone to traumatic injuries, leading to the loss of motor and sensory
functions. Even though surgical repair is possible, the extent of functional recovery after the …

In humans, most neurons are born during embryonic development and have to persist
throughout the entire lifespan of an individual. Thus, human neurons have to develop elaborate …

The clinical “gold standard” technique for attempting to restore function to nerves with a gap
is to bridge the gap with sensory autografts. However, autografts induce good to excellent …