[HTML][HTML] SARS-CoV-2 engages inflammasome and pyroptosis in human primary monocytes
…, N Fintelman-Rodrigues, CQ Sacramento… - Cell death …, 2021 - nature.com
Infection by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been
associated with leukopenia and uncontrolled inflammatory response in critically ill patients. A …
associated with leukopenia and uncontrolled inflammatory response in critically ill patients. A …
[HTML][HTML] Lipid droplets fuel SARS-CoV-2 replication and production of inflammatory mediators
…, VC Soares, AC Ferreira, CQ Sacramento… - PLoS …, 2020 - journals.plos.org
Viruses are obligate intracellular parasites that make use of the host metabolic machineries
to meet their biosynthetic needs. Thus, identifying the host pathways essential for the virus …
to meet their biosynthetic needs. Thus, identifying the host pathways essential for the virus …
[HTML][HTML] The clinically approved antiviral drug sofosbuvir inhibits Zika virus replication
CQ Sacramento, GR de Melo, CS de Freitas… - Scientific reports, 2017 - nature.com
Zika virus (ZIKV) is a member of the Flaviviridae family, along with other agents of clinical
significance such as dengue (DENV) and hepatitis C (HCV) viruses. Since ZIKV causes …
significance such as dengue (DENV) and hepatitis C (HCV) viruses. Since ZIKV causes …
Atazanavir, alone or in combination with ritonavir, inhibits SARS-CoV-2 replication and proinflammatory cytokine production
N Fintelman-Rodrigues, CQ Sacramento… - Antimicrobial agents …, 2020 - Am Soc Microbiol
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is already responsible for
far more deaths than previous pathogenic coronaviruses (CoVs) from 2002 and 2012. The …
far more deaths than previous pathogenic coronaviruses (CoVs) from 2002 and 2012. The …
In vitro antiviral activity of the anti-HCV drugs daclatasvir and sofosbuvir against SARS-CoV-2, the aetiological agent of COVID-19
CQ Sacramento, N Fintelman-Rodrigues… - Journal of …, 2021 - academic.oup.com
Background Current approaches of drug repurposing against COVID-19 have not proven
overwhelmingly successful and the SARS-CoV-2 pandemic continues to cause major global …
overwhelmingly successful and the SARS-CoV-2 pandemic continues to cause major global …
Platelet-monocyte interaction amplifies thromboinflammation through tissue factor signaling in COVID-19
…, MM de Campos, CQ Sacramento… - Blood …, 2022 - ashpublications.org
Accumulating evidence into the pathogenesis of COVID-19 highlights a hypercoagulability
state with high risk of life-threatening thromboembolic complications. However, the …
state with high risk of life-threatening thromboembolic complications. However, the …
Design, synthesis, and antiviral activity of new 1H-1,2,3-triazole nucleoside ribavirin analogs
…, MDS Peçanha, CQ Sacramento… - Medicinal Chemistry …, 2014 - Springer
Ribavirin is a broad antiviral compound with demonstrated activity against herpes simplex
virus (HSV), human immunodeficiency virus HIV-1, influenza virus, respiratory syncytial virus, …
virus (HSV), human immunodeficiency virus HIV-1, influenza virus, respiratory syncytial virus, …
[HTML][HTML] Combination of antiviral drugs inhibits SARS-CoV-2 polymerase and exonuclease and demonstrates COVID-19 therapeutic potential in viral cell culture
X Wang, CQ Sacramento, S Jockusch… - Communications …, 2022 - nature.com
SARS-CoV-2 has an exonuclease-based proofreader, which removes nucleotide inhibitors
such as Remdesivir that are incorporated into the viral RNA during replication, reducing the …
such as Remdesivir that are incorporated into the viral RNA during replication, reducing the …
Repurposing the Ebola and Marburg Virus Inhibitors Tilorone, Quinacrine, and Pyronaridine: In Vitro Activity against SARS-CoV-2 and Potential Mechanisms
…, TR Lane, LV Tse, BL Yount, CQ Sacramento… - ACS …, 2021 - ACS Publications
Severe acute respiratory coronavirus 2 (SARS-CoV-2) is a newly identified virus that has
resulted in over 2.5 million deaths globally and over 116 million cases globally in March, 2021. …
resulted in over 2.5 million deaths globally and over 116 million cases globally in March, 2021. …
[HTML][HTML] Simvastatin downregulates the SARS-CoV-2-induced inflammatory response and impairs viral infection through disruption of lipid rafts
…, M Mattos, BS Gonçalves, CQ Sacramento… - Frontiers in …, 2022 - frontiersin.org
Coronavirus disease 2019 (COVID-19) is currently a worldwide emergency caused by
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). In observational clinical …
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). In observational clinical …