Definitive hematopoiesis emerges during embryogenesis via an endothelial-to-hematopoietic
transition. We attempted to induce this process in mouse fibroblasts by screening a panel …

Direct reprogramming involves the enforced re-expression of key transcription factors to
redefine a cellular state. The nephron progenitor population of the embryonic kidney gives rise …

Upon fertilization, embryos undergo chromatin reprogramming and genome activation;
however, the mechanisms that regulate these processes are poorly understood. Here, we …

Nuclear reprogramming has reshaped stem cell science and created new avenues for cell-based
therapies. The ability to bestow any given phenotype upon adult cells regardless of …

Tissue repair requires a highly coordinated cellular response to injury. In the lung, alveolar
type 2 cells (AT2s) act as stem cells to replenish both themselves and alveolar type 1 cells (…

Tissue repair requires a highly coordinated cellular response to injury. In the lung, alveolar
type 2 (AT2) cells act as stem cells and can replace both themselves and alveolar type 1 cells …

The adult kidney has a limited capacity to repair. The only characterized nephron progenitor
cell population that exists is the embryonic cap mesenchyme (CM), which is present only …

Objective Whether short-term, low-potency opioid prescriptions for acute pain lead to future
at-risk opioid use remains controversial and inadequately characterized. Our objective was …

Purpose The purpose of this paper is to investigate how local supply chains prepare for and
respond to the threats and opportunities presented by constitutional change, thereby …

Although there are many examples of contemporary directional selection, evidence for
responses to selection that match predictions are often missing in quantitative genetic studies of …