Bipolar disorder is a highly heritable psychiatric disorder. We performed a genome-wide
association study (GWAS) including 20,352 cases and 31,358 controls of European descent, …

Genomic stability is critical for the clinical use of human embryonic and induced pluripotent
stem cells. We performed high-resolution SNP (single-nucleotide polymorphism) analysis on …

Post-traumatic stress disorder (PTSD) occurs in 5–10% of the population and is twice as
common in women as in men. Although trauma exposure is the precipitating event for PTSD to …

Consistent failure over the past few decades to reduce the high prevalence of stress-related
disorders has motivated a search for alternative research strategies. Resilience refers to the …

The Psychiatric Genomics Consortium (PGC) is the largest consortium in the history of
psychiatry. This global effort is dedicated to rapid progress and open science, and in the past …

Bipolar disorder is a complex neuropsychiatric disorder that is characterized by intermittent
episodes of mania and depression; without treatment, 15% of patients commit suicide 1 . …

The risk of posttraumatic stress disorder (PTSD) following trauma is heritable, but robust
common variants have yet to be identified. In a multi-ethnic cohort including over 30,000 PTSD …

Background Lithium is a first-line treatment in bipolar disorder, but individual response is
variable. Previous studies have suggested that lithium response is a heritable trait. However, …

Importance Posttraumatic stress disorder (PTSD) has been associated in cross-sectional
studies with peripheral inflammation. It is not known whether this observed association is the …

Bipolar affective disorder (BPAD) is suspected to arise in part from malfunctions of the circadian
system, a system that enables adaptation to a daily and seasonally cycling environment. …