CRISPR–Cas technologies have enabled programmable gene editing in eukaryotes and
prokaryotes. However, the leading Cas9 and Cas12a enzymes are limited in their ability to …

CRISPR–Cas adaptive immune systems protect bacteria and archaea against their invading
genetic parasites, including bacteriophages/viruses and plasmids. In response to this …

Bacterial CRISPR-Cas systems employ RNA-guided nucleases to destroy phage (viral) DNA.
Phages, in turn, have evolved diverse "anti-CRISPR" proteins (Acrs) to counteract acquired …

Bacteriophages must rapidly deploy anti-CRISPR proteins (Acrs) to inactivate the RNA-guided
nucleases that enforce CRISPR-Cas adaptive immunity in their bacterial hosts. Listeria …

Saliva as a sample matrix has been an attractive alternative for the detection of SARS-CoV-2.
However, due to potential variability in collection and processing steps, evaluating a …

The testing capacity of the laboratory is paramount for better control of the pandemic caused
by SARS-CoV-2. The pooling method is promising to increase testing capacity, and the use …

Background: Administration of pharmacogenomics (PGx) testing in clinical practice has
been suboptimal, presumably due to lack of PGx education. Here, we aim to evaluate the …

Background: Allopurinol is the most commonly used drug for the treatment of gout arthritis.
However, the use of allopurinol is associated with severe cutaneous adverse reactions (…

In the version of this Article originally published, the authors mistakenly failed to include the
following funding in the Acknowledgements:“This research was developed with funding from …

Aim: The clinical utility of pharmacogenomics (PGx) has been gaining traction alongside
growing evidence that adverse drug reactions (ADRs) have significant genetic associations. …