Aims BMP9 and BMP10 mutations were recently identified in patients with pulmonary arterial
hypertension, but their specific roles in the pathogenesis of the disease are still unclear. …

Clear cell renal cell carcinoma (ccRCC) is the third type of urologic cancer. At time of
diagnosis, 30% of cases are metastatic with no effect of chemotherapy or radiotherapy. Current …

Simple Summary Renal cell carcinoma (RCC) is the eighth leading malignancy in the world,
accounting for 4% of all cancers with poor outcome when metastatic. Protein kinases are …

Tumor development progresses through a complex path of biomechanical changes leading
first to cell growth and contraction and then cell deadhesion, scattering, and invasion. …

Sulfs represent a class of unconventional sulfatases which provide an original post-synthetic
regulatory mechanism for heparan sulfate polysaccharides and are involved in multiple …

Background Vascular endothelial (VE)-cadherin is an endothelial cell-specific protein
responsible for endothelium integrity. Its adhesive properties are regulated by post-translational …

Altered expression of regulatory RNA-binding proteins (RBPs) in cancer leads to abnormal
expression of mRNAs encoding many factors involved in cancer hallmarks. While …

Aims BMP9 is a high affinity ligand of ALK1 and endoglin receptors that are mutated in the
rare genetic vascular disorder Hereditary Hemorrhagic Telangiectasia (HHT). We have …

Preeclampsia (PE) is the most threatening pathology of human pregnancy. Its development
is thought to be due to a failure in the invasion of trophoblast cells that establish the feto-…

Potent inhibitors of PI3K (GDC-0941) and Src (Saracatinib) exhibit as individual agents,
excellent oral anticancer activity in preclinical models and have entered phase II clinical trials in …