Cinnabarinic and xanthurenic acids are kynurenine metabolites generated by oxidative
dimerization of 3-hydroxyanthranilic acid and transamination of 3-hydroxykynurenine, …

… The authors confirm that the Principal Investigator for this paper is Caroline S. Copeland.
She had direct responsibility for the data (note: patient consent was not applicable to this study …

Whole-cell patch-clamp electrophysiological recording is a powerful technique for studying
cellular function. While in vivo patch-clamp recording has recently benefited from automation, …

Background: Ketamine is a phencyclidine derivative with dissociative anaesthetic properties.
Increasing numbers of individuals in England take ketamine recreationally. Information on …

Background: Recreational lysergic acid diethylamide (LSD) use is growing in popularity amid
increasing research interest on psychedelics and their possible therapeutic potential yet; …

Background and aims On November 8th , 2022, the United States Food and Drug
Administration (FDA) issued a statement alerting healthcare professionals to the increasing …

Aim This research aimed to describe how the characteristics of deaths following drug use
changed during the COVID-19 pandemic in England, and how this can inform future strategy to …

Recent years have seen substantial developments in technology for imaging neural circuits,
raising the prospect of large-scale imaging studies of neural populations involved in …

Background: ‘Legal highs’ began appearing in the UK in the mid-2000s. Whilst many of these
substances were controlled under the 1971 Misuse of Drugs Act, novel compounds and …

Aim: To identify drug-related death trends associated with synthetic cannabinoid receptor
agonists (SCRAs) reported to the National Programme on Substance Abuse Deaths (NPSAD) …