Ku is an abundant, highly conserved DNA binding protein found in both prokaryotes and
eukaryotes that plays essential roles in the maintenance of genome integrity. In eukaryotes, Ku …

Glucocorticoids potentiate the early steps of preadipocyte differentiation and promote obesity
in Cushing's syndrome and during prolonged steroid therapy. We show that glucocorticoids …

The POU-domain transcription factor Oct-1 is widely expressed in adult tissues and has been
proposed to regulate a large group of target genes. Microarray expression profiling was …

The Ku heterodimer (Ku70/Ku80) is a main component of the nonhomologous end-joining (NHEJ)
pathway that repairs DNA double-strand breaks (DSBs). Ku binds the broken DNA …

The multi-subunit C-terminal to LisH (CTLH) complex is the mammalian homologue of the
yeast Gid E3 ubiquitin ligase complex. In this study, we investigated the human CTLH complex …

The predominantly pre-synaptic intrinsically disordered protein α-synuclein is prone to
misfolding and aggregation in synucleinopathies, such as Parkinson’s disease (PD) and …

Multi-subunit E3 ligases facilitate ubiquitin transfer by coordinating various substrate
receptor subunits with a single catalytic center. Small molecules inducing targeted protein …

The CRISPR/Cas9 nuclease is commonly used to make gene knockouts. The blunt DNA
ends generated by cleavage can be efficiently ligated by the classical nonhomologous end-…

Ubiquitination is an essential post‐translational modification that regulates protein stability or
function. Its substrate specificity is dictated by various E3 ligases. The human C‐terminal to …

Since its discovery in 1981, the Ku complex has been extensively studied under multiple
cellular contexts, with most work focusing on Ku in terms of its essential role in non-homologous …