A randomised, assessor- and participant-blind, sham-controlled trial was conducted to
assess the safety and feasibility of adding transcranial direct current stimulation (tDCS) to …

Objectives Although non‐invasive ventilation ( NIV ) can benefit survival and quality of life, it
is rejected by a substantial proportion of people with motor neurone disease ( MND ). The …

… Rog and Young participated in the acquisition of trial data. Dr. Friede independently …
Young and Nurmikko have both received funding for research (in excess of $10,000) from GW …

The fungal family Clavicipitaceae includes plant symbionts and parasites that produce
several psychoactive and bioprotective alkaloids. The family includes grass symbionts in the …

Background Spasticity is a common problem in multiple sclerosis (MS) patients causing pain,
spasms, loss of function and difficulties in nursing care. A variety of oral and parenteral …

Lolitrems are a structurally diverse group of indole-diterpene mycotoxins synthesized by
Epichloë/Neotyphodium endophytes in association with Pooid grasses. Using suppression …

Background: Central neuropathic pain (CNP), pain initiated or caused by a primary lesion or
dysfunction of the central nervous system, occurs in ~28% of patients with multiple sclerosis …

The epichloid fungi – comprising sexual Epichloë species and asexual Neotyphodium
species – are symbionts of cool-season grasses (subfamily Poöideae), mostly vertically …

The closely linked fitness of the Epichloë symbiont and the host grass is presumed to align
the coevolution of the species towards specialization and mutually beneficial cooperation. …

The ergot alkaloid biosynthesis system has become an excellent model to study evolutionary
diversification of specialized (secondary) metabolites. This is a very diverse class of …