Circadian clocks coordinate physiology and behavior with the 24h solar day to provide
temporal homeostasis with the external environment. The molecular clocks that drive these …

Purification of recombinant proteins for biochemical assays and structural studies is time‐consuming
and presents inherent difficulties that depend on the optimization of protein stability. …

Human body-surface epithelia coexist in close association with complex bacterial communities
and are protected by a variety of antibacterial proteins. C-type lectins of the RegIII family …

Cryptochromes are blue-light photoreceptors that regulate a variety of responses such as
growth and circadian rhythms in organisms ranging from bacteria to humans. Cryptochromes …

Circadian clocks are ubiquitous timing systems that induce rhythms of biological activities in
synchrony with night and day. In cyanobacteria, timing is generated by a posttranslational …

The molecular circadian clock in mammals is generated from transcriptional activation by
the bHLH-PAS transcription factor CLOCK–BMAL1 and subsequent repression by PERIOD …

RegIII proteins are secreted C-type lectins that kill Gram-positive bacteria and play a vital role
in antimicrobial protection of the mammalian gut. RegIII proteins bind their bacterial targets …

Multisite phosphorylation of the PERIOD 2 (PER2) protein is the key step that determines the
period of the mammalian circadian clock. Previous studies concluded that an unidentified …

Cryptochromes use near-UV/blue light to regulate a variety of growth and adaptive process.
Recent biochemical studies demonstrate that the Cryptochrome-Drosophila, Arabidopsis, …

Cryptochromes are flavoproteins that exhibit high sequence and structural similarity to the
light‐dependent DNA‐repair enzyme, photolyase. Cryptochromes have lost the ability to …