A hallmark pathological feature of the neurodegenerative diseases amyotrophic lateral
sclerosis (ALS) and frontotemporal dementia (FTD) is the depletion of RNA-binding protein TDP-…

Background It is essential to determine the specificity of AV-1451 PET for tau in brain
imaging by using pathological comparisons. We performed autoradiography in autopsy-confirmed …

Tau aggregation into insoluble filaments is the defining pathological hallmark of tauopathies.
However, it is not known what controls the formation and templated seeding of strain-…

The major genetic cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis
(ALS) is a C9orf72 G 4 C 2 repeat expansion 1 , 2 . Proposed mechanisms by which the …

Functional loss of TDP-43, an RNA binding protein genetically and pathologically linked to
amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), leads to the inclusion …

Misfolding and aggregation of disease-specific proteins, resulting in the formation of
filamentous cellular inclusions, is a hallmark of neurodegenerative disease with characteristic …

TAR DNA-binding protein 43 (TDP-43) inclusions are a pathological hallmark of frontotemporal
dementia (FTD) and amyotrophic lateral sclerosis (ALS), including cases caused by G 4 …

Frontotemporal dementia and amyotrophic lateral sclerosis (FTD-ALS) are associated with
both a repeat expansion in the C9orf72 gene and mutations in the TANK-binding kinase 1 (…

Brain imaging studies of patients with COVID-19 show evidence of macro- and microhemorrhagic
lesions, multifocal white matter hyperintensities, and lesions consistent with posterior …

An expanded hexanucleotide repeat in C9orf72 causes amyotrophic lateral sclerosis and
frontotemporal dementia (c9FTD/ALS). Therapeutics are being developed to target RNAs …