We conducted a meta-analysis of genome-wide association studies of systolic (SBP) and
diastolic (DBP) blood pressure in 19,608 subjects of east Asian ancestry from the AGEN-BP …

Central abdominal fat is a strong risk factor for diabetes and cardiovascular disease. To
identify common variants influencing central abdominal fat, we conducted a two-stage genome-…

Background Since insulin resistance is thought to be the underlying mechanism for metabolic
syndrome, affected individuals might be sensitive to a dietary sodium intervention. We …

Objective To examine factors related to blood pressure (BP) responses to dietary sodium and
potassium interventions. Methods We conducted a dietary feeding study that included a 7-…

Importance Atrial fibrillation (AF) is the most common arrhythmia affecting 1% of the population.
Young individuals with AF have a strong genetic association with the disease, but the …

The increasing volume of whole-genome sequence (WGS) and multi-omics data requires
new approaches for analysis. As one solution, we have created the cloud-based Analysis …

Objective The withdrawal of cerivastatin involved an uncommon but serious adverse reaction,
rhabdomyolysis. The bimodal response, rhabdomyolysis in a small proportion of users, …

The heritability of blood pressure responses to dietary intervention has not been well studied.
We examined the heritability of blood pressure responses to dietary sodium and potassium …

Background— Blood pressure (BP) responses to dietary sodium and potassium intervention
and cold pressor test vary considerably among individuals. We aimed to identify novel …

We performed a genomewide linkage analysis of six separate measurements of body mass
index (BMI) taken over a span of 28 years, from 1971 to 1998, in the Framingham Heart …