Small-molecule inhibitors of the serine dipeptidases DPP8 and DPP9 (DPP8/9) induce a lytic
form of cell death called pyroptosis in mouse and human monocytes and macrophages 1 , …

T cell acute lymphoblastic leukemia (T-ALL) is an aggressive cancer that is frequently associated
with activating mutations in NOTCH1 and dysregulation of MYC. Here, we performed 2 …

Although the treatment of acute myeloid leukemia (AML) has improved substantially in the
past three decades, more than half of all patients develop disease that is refractory to …

Genomic rearrangements are a hallmark of human cancers. Here, we identify the piggyBac
transposable element derived 5 (PGBD5) gene as encoding an active DNA transposase …

Despite intense efforts, the cure rates of childhood and adult solid tumors are not satisfactory.
Resistance to intensive chemotherapy is common, and targets for molecular therapies are …

In acute myeloid leukemia (AML), chemotherapy resistance remains prevalent and poorly
understood. Using functional proteomics of patient AML specimens, we identified MEF2C …

Genomic rearrangements are a hallmark of most childhood tumors, including medulloblastoma,
one of the most common brain tumors in children, but their causes remain largely …

Recent developments in quantitative high-resolution mass spectrometry have led to significant
improvements in the sensitivity and specificity of the biochemical analyses of cellular …

Activating mutations of the interleukin‐7 receptor ( IL 7R) occur in approximately 10% of patients
with T cell acute lymphoblastic leukaemia (T‐ ALL ). Most mutations generate a cysteine …

Sickle cell disease (SCD) affects millions of people worldwide and represents the most common
monogenic disease of mankind (1). It is due to a homozygous T to A transversion in the β…