Targeted gene addition in human CD34+ hematopoietic cells for correction of X-linked chronic granulomatous disease
…, A Reik, PQ Liu, L Li, X Wu, L Su, C Raley… - Nature …, 2016 - nature.com
Gene therapy with genetically modified human CD34 + hematopoietic stem and progenitor
cells (HSPCs) may be safer using targeted integration (TI) of transgenes into a genomic 'safe …
cells (HSPCs) may be safer using targeted integration (TI) of transgenes into a genomic 'safe …
[HTML][HTML] Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts
…, Y Liu, P Macdonald, A Melnikov, C Raley… - Nature …, 2016 - nature.com
Pneumocystis jirovecii is a major cause of life-threatening pneumonia in immunosuppressed
patients including transplant recipients and those with HIV/AIDS, yet surprisingly little is …
patients including transplant recipients and those with HIV/AIDS, yet surprisingly little is …
[HTML][HTML] Emergence of the Ug99 lineage of the wheat stem rust pathogen through somatic hybridisation
Parasexuality contributes to diversity and adaptive evolution of haploid (monokaryotic) fungi.
However, non-sexual genetic exchange mechanisms are not defined in dikaryotic fungi (…
However, non-sexual genetic exchange mechanisms are not defined in dikaryotic fungi (…
Combined HIV-1 sequence and integration site analysis informs viral dynamics and allows reconstruction of replicating viral ancestors
…, A Wiegand, J Spindler, C Raley… - Proceedings of the …, 2019 - National Acad Sciences
Understanding HIV-1 persistence despite antiretroviral therapy (ART) is of paramount
importance. Both single-genome sequencing (SGS) and integration site analysis (ISA) provide …
importance. Both single-genome sequencing (SGS) and integration site analysis (ISA) provide …
[HTML][HTML] A benchmark study on error assessment and quality control of CCS reads derived from the PacBio RS
…, BT Sherman, X Hu, K Jones, C Raley… - Journal of data …, 2013 - ncbi.nlm.nih.gov
PacBio RS, a newly emerging third-generation DNA sequencing platform, is based on a real-time,
single-molecule, nano-nitch sequencing technology that can generate very long reads …
single-molecule, nano-nitch sequencing technology that can generate very long reads …
De Novo Assembly and Phasing of Dikaryotic Genomes from Two Isolates of Puccinia coronata f. sp. avenae, the Causal Agent of Oat Crown Rust
…, J Sperschneider, B Schwessinger, C Raley… - MBio, 2018 - Am Soc Microbiol
Oat crown rust, caused by the fungus Pucinnia coronata f. sp. avenae, is a devastating disease
that impacts worldwide oat production. For much of its life cycle, P. coronata f. sp. avenae …
that impacts worldwide oat production. For much of its life cycle, P. coronata f. sp. avenae …
[HTML][HTML] Towards better precision medicine: PacBio single-molecule long reads resolve the interpretation of HIV drug resistant mutation profiles at explicit …
C Raley, MK Jiang, X Zheng, D Liang… - Journal of data …, 2016 - ncbi.nlm.nih.gov
Abstract Development of HIV-1 drug resistance mutations (HDRMs) is one of the major reasons
for the clinical failure of antiretroviral therapy. Treatment success rates can be improved …
for the clinical failure of antiretroviral therapy. Treatment success rates can be improved …
[HTML][HTML] Genome Assembly and Annotation of the Trichoplusia ni Tni-FNL Insect Cell Line Enabled by Long-Read Technologies
K Talsania, M Mehta, C Raley, Y Kriga, S Gowda… - Genes, 2019 - mdpi.com
Background: Trichoplusia ni derived cell lines are commonly used to enable recombinant
protein expression via baculovirus infection to generate materials approved for clinical use …
protein expression via baculovirus infection to generate materials approved for clinical use …
[HTML][HTML] Hospital antimicrobial stewardship: profiling the oral microbiome after exposure to COVID-19 and antibiotics
P Buendia, K Fernandez, C Raley… - Frontiers in …, 2024 - frontiersin.org
Introduction During the COVID-19 Delta variant surge, the CLAIRE cross-sectional study
sampled saliva from 120 hospitalized patients, 116 of whom had a positive COVID-19 PCR test. …
sampled saliva from 120 hospitalized patients, 116 of whom had a positive COVID-19 PCR test. …
[HTML][HTML] Distinguishing highly similar gene isoforms with a clustering-based bioinformatics analysis of PacBio single-molecule long reads
M Liang, C Raley, X Zheng, G Kutty, E Gogineni… - BioData mining, 2016 - Springer
Background Gene isoforms are commonly found in both prokaryotes and eukaryotes. Since
each isoform may perform a specific function in response to changing environmental …
each isoform may perform a specific function in response to changing environmental …