10.7554/eLife.26980.001 Recent genome analyses have identified recurrent mutations in
the cohesin complex in a wide range of human cancers. Here we demonstrate that the most …

Understanding urothelial stem cell biology and differentiation has been limited by the lack of
methods for their unlimited propagation. Here, we establish mouse urothelial organoids that …

Coastal areas host some of the planet’s most productive ecosystems, providing life-sustaining
ecological services and several benefits to humankind, while also being some of the most …

Global ocean O 2 content has varied significantly across the eons, both shaping and being
shaped by the evolutionary history of life on planet Earth. Indeed, past O 2 fluctuations have …

Advances in ocean observing technologies and modeling provide the capacity to revolutionize
the management of living marine resources. While traditional fisheries management …

Aside from being one of the most fascinating groups of marine organisms, cephalopods play
a major role in marine food webs, both as predators and as prey, while representing key …

In a digital era where terabytes of structured and unstructured records are created and
stored every minute, the importance of collecting small amounts of high quality data is often …

Marine heatwaves (MHWs) are extreme weather events featuring abnormally high seawater
temperature, and expected to increase in frequency, duration and severity over this century. …

Ocean acidification is a consequence of chemical changes driven mainly by a continuous
uptake of carbon dioxide, resulting in pH decrease. This phenomenon represents an …

The dramatic decline of European eel (Anguilla anguilla) populations over recent decades
has attracted considerable attention and concern. Furthermore, little is known about the …