Since the discovery of cisplatin more than 40 years ago and its clinical introduction in the
1970s an enormous amount of research has gone into elucidating the mechanism of action of …

Background Adverse drug reactions (ADR) are a common reason for emergency room visits
and for hospitalization. An ADR is said to have occurred when the patient’s symptoms and …

Green tea polyphenols may contribute to the prevention of cancer and other diseases. To
learn more about the pharmacokinetics and interindividual variation of green tea polyphenols …

Aim Epidermal growth factor receptor inhibitor (EGFRI) induced skin toxicity has a prognostic
value suggesting skin toxicity can be a useful surrogate marker for successful epidermal …

Zonation of metabolic activities within specific structures and cell types is a phenomenon of
liver organization and ensures complementarity of variant liver functions like protein …

METHODS: A randomized, double-blind trial of GTE standardized to 150 mg of EGCG bid vs
placebo over 3 years was conducted to prevent colorectal adenomas (n= 1,001 with colon …

Background and aims The Hepatitis E virus hijacks the endosomal system for its release.
These structures are highly dependent on cholesterol. Hence, this study investigates the impact …

Objective Pharmacogenomics (PGx) is a clinically significant factor in the safe and efficacious
use of medicines. While PGx knowledge is abundant for other populations, there are …

Neural stem cells (NSCs) generate new neurons in vivo and in vitro throughout adulthood
and therefore are physiologically and clinically relevant. Unveiling the mechanisms regulating …

Zika virus (ZIKV) is a mosquito-borne virus, which can cause brain abnormalities in newborns,
including microcephaly. MicroRNAs (miRNAs) are small non-coding RNAs, which post- …