The Tasmanian devil, a marsupial carnivore, is endangered because of the emergence of a
transmissible cancer known as devil facial tumor disease (DFTD). This fatal cancer is …

Modelling the complex process of neuromuscular signalling is key to understanding not
only normal circuit function but also importantly the mechanisms underpinning a range of …

Degeneration of the distal axon and neuromuscular junction (NMJ) is considered a key and
early feature of the pathology that accompanies motor neuron loss in people with …

Alterations in upper motor neuron excitability are one of the earliest phenomena clinically
detected in ALS, and in 97 % of cases, the RNA/DNA binding protein, TDP-43, is mislocalised …

TDP-43 is a major protein component of pathological neuronal inclusions that are present in
frontotemporal dementia and amyotrophic lateral sclerosis. We report that TDP-43 plays an …

There has been growing interest in the axon as the initial focus of pathological change in a
number of neurodegenerative diseases of the central nervous system. This review …

Amyotrophic lateral sclerosis (ALS) is a chronic neurodegenerative disease pathologically
characterised by mislocalisation of the RNA‐binding protein TAR‐DNA‐binding protein 43 (…

Amyotrophic lateral sclerosis (ALS) is an aggressive multifactorial disease converging on a
common pathology: the degeneration of motor neurons (MNs), their axons and …

There is a desperate need for targeted therapeutic interventions that slow the progression of
amyotrophic lateral sclerosis (ALS). ALS is a disorder with heterogeneous onset, which then …

Glutamate excitotoxicity is a major pathogenic process implicated in many neurodegenerative
conditions, including AD (Alzheimer's disease) and following traumatic brain injury. …