The E6 oncoprotein derived from tumour-associated human papillomaviruses (HPVs) binds
to and induces the degradation of the cellular tumour-suppressor protein p53. A common …

Oxidative stress and mutagenic DNA lesions formed by reactive oxygen species (ROS) are
linked to human malignancy. Clinical treatments inducing chronic oxidative stress may …

The p73 protein, a homologue of the tumour-suppressor protein p53, can activate p53-responsive
promoters and induce apoptosis in p53-deficient cells. Here we report that some …

The role of human papillomavirus (HPV) in anogenital carcinogenesis is established firmly,
but a similar role in non‐melanoma skin cancer remains speculative. Certain …

Basal cell carcinoma (BCC) is the most common malignant tumour in white populations.
Multidisciplinary experts from the European Dermatology Forum, the European Association of …

Ultraviolet B (UVB) damage is recognized as the most important etiological factor in the
development of skin cancer. Human papillomaviruses (HPV) have also been implicated in the …

Cutaneous SCC (cSCC) is the most frequently occuring skin cancer with metastatic potential
and can manifest rapidly as a common side effect in patients receiving systemic kinase …

Recent studies suggest a role of cutaneous human papillomaviruses (HPV) in non-melanoma
skin cancer (NMSC) development. In this study viral DNA loads of six frequent HPV types …

Cutaneous squamous cell carcinoma (cSCC) has a high tumour mutational burden (50
mutations per megabase DNA pair). Here, we combine whole-exome analyses from 40 primary …

In order to update recommendations on treatment, supportive care, education and follow-up
of patients with invasive cutaneous squamous cell carcinoma (cSCC), a multidisciplinary …