Cyclin B1–Cdk1 is the key initiator of mitosis, but when and where activation occurs has not
been precisely determined in mammalian cells. Activation may occur in the nucleus or …

During normal development, the epidermis and hair follicle are distinct lineage compartments
maintained by independent stem cell populations. Both epidermal and follicular …

The regeneration of the skin and its appendages is thought to occur by the regulated activation
of a dedicated stem cell population. A population of cells in the bulge region of the hair …

We have found that key mitotic regulators show distinct patterns of degradation during exit
from mitosis in human cells. Using a live-cell assay for proteolysis, we show that two of these …

The activity of keratinocytes in the hair follicle is regulated by signals from a specialized
mesenchymal niche, the dermal papilla (DP). Here, mice expressing cre recombinase in the DP …

Mutations in the gene encoding the microtubule (MT)‐severing protein spastin are the most
common cause of hereditary spastic paraplegia, a genetic condition in which axons of the …

We report the identification and expression pattern of a full-length human cDNA and a partial
mouse cDNA encoding cyclin B3. Cyclin B3 (CCNB3) is conserved from Caenorhabditis …

The temporal control of mitotic protein degradation remains incompletely understood. In
particular, it is unclear why the mitotic checkpoint prevents the anaphase-promoting complex/…

Background Control of mitotic cell cycles by the anaphase-promoting complex or cyclosome
(APC/C) ubiquitin ligase depends on its coactivators Cdc20 and Cdh1. APC/C Cdc20 is …

The Aurora-A kinase regulates cell division by phosphorylating multiple downstream targets
in the mitotic apparatus. Aurora-A is frequently overexpressed in tumor cells and it is …