We have identified the mutation responsible for the autosomal recessive wasted (wst)
mutation of the mouse. Wasted mice are characterized by wasting and neurological and …

10.7554/eLife.03164.001 Translation elongation factor eEF1A has a well-defined role in protein
synthesis. In this study, we demonstrate a new role for eEF1A: it participates in the entire …

Background The tissue-specific translation elongation factor eEF1A2 was recently shown to
be a potential oncogene that is overexpressed in ovarian cancer. Although there is no direct …

The prokaryotic translation elongation factors were identified as essential cofactors for RNA-dependent
RNA polymerase activity of the bacteriophage Qβ more than 40 years ago. A …

Clones encoding the breast tumor kinase BRK were isolated from a normal human small
intestinal cDNA library that was screened with the cDNA encoding the mouse epithelial-specific …

Background Despite sharing 92% sequence identity, paralogous human translation elongation
factor 1 alpha-1 (eEF1A1) and elongation factor 1 alpha-2 (eEF1A2) have different but …

In most mouse models of disease, the outward manifestation of a disorder can be measured
easily, can be assessed with a trivial test such as hind limb clasping, or can even be …

Background Exome sequencing has led to the discovery of mutations in novel causative
genes for epilepsy. One such gene is EEF 1A2, encoding a neuromuscular specific translation …

Background The canonical function of EEF1A2, normally expressed only in muscle, brain,
and heart, is in translational elongation, but recent studies suggest a non-canonical function …

The multi‐subunit eEF1 complex plays a crucial role in de novo protein synthesis. The
central functional component of the complex is eEF1A, which occurs as two independently …