The genes for two new P-type ATPases, PMRl and PMRP, have been identified in yeast. A
comparison of the deduced sequences of the PMR proteins with other known ion pumps …

Macropinocytosis is a mechanism for the nonspecific bulk uptake and internalisation of
extracellular fluid. This plays specific and distinct roles in diverse cell types such as macrophages…

Despite ongoing (macro)pinocytosis of extracellular fluid, the volume of the endocytic
pathway remains unchanged. To investigate the underlying mechanism, we used high-resolution …

Macropinocytosis is an ancient mechanism that allows cells to harvest nutrients from
extracellular media, which also allows immune cells to sample antigens from their surroundings. …

… Higgins, and M. O’Donoghue for technical assistance. We also thank Kevin Buckley for
assistance with initial growth studies. This work was supported by a grant from the European …

Phosphoinositide signaling lipids (PIPs) are key regulators of membrane identity and
trafficking. Of these, PI (3, 5) P2 is one of the least well-understood, despite key roles in many …

By engulfing potentially harmful microbes, professional phagocytes are continually at risk
from intracellular pathogens. To avoid becoming infected, the host must kill pathogens in the …

Engulfment of extracellular material by phagocytosis or macropinocytosis depends on the
ability of cells to generate specialized cup-shaped protrusions. To effectively capture and …

The gene lipA of Pseudomonas cepacia DSM 3959 encodes a prelipase from which a signal
peptide is cleaved during secretion, producing a mature extracellular lipase. Expression of …

A glutathione S-transferase (GST) was purified to homogeneity from the white-rot fungus,
Phanerochaete chrysosporium, by affinity chromatography on glutathione–agarose followed by …