[HTML][HTML] Dose-dependent response to infection with SARS-CoV-2 in the ferret model and evidence of protective immunity
…, TH Hender, HE Humphries, L Hunter, CMK Ho… - Nature …, 2021 - nature.com
There is a vital need for authentic COVID-19 animal models to enable the pre-clinical evaluation
of candidate vaccines and therapeutics. Here we report a dose titration study of SARS-…
of candidate vaccines and therapeutics. Here we report a dose titration study of SARS-…
[HTML][HTML] Comparison of rhesus and cynomolgus macaques as an infection model for COVID-19
…, R Halkerston, DJ Harris, T Hender, CMK Ho… - Nature …, 2021 - nature.com
A novel coronavirus, SARS-CoV-2, has been identified as the causative agent of the current
COVID-19 pandemic. Animal models, and in particular non-human primates, are essential to …
COVID-19 pandemic. Animal models, and in particular non-human primates, are essential to …
[HTML][HTML] Prophylactic intranasal administration of a TLR2/6 agonist reduces upper respiratory tract viral shedding in a SARS-CoV-2 challenge ferret model
…, R Cobb, S Dowall, SA Fotheringham, CMK Ho… - …, 2021 - thelancet.com
Background The novel human coronavirus SARS-CoV-2 is a major ongoing global threat
with huge economic burden. Like all respiratory viruses, SARS-CoV-2 initiates infection in the …
with huge economic burden. Like all respiratory viruses, SARS-CoV-2 initiates infection in the …
Dose-dependent response to infection with SARS-CoV-2 in the ferret model: evidence of protection to re-challenge
…, DJ Harris, HE Humphries, L Hunter, CMK Ho… - BioRxiv, 2020 - biorxiv.org
In December 2019 an outbreak of coronavirus disease (COVID-19) emerged in Wuhan,
China. The causative agent was subsequently identified and named severe acute respiratory …
China. The causative agent was subsequently identified and named severe acute respiratory …
[HTML][HTML] ChAdOx1 nCoV-19 protection against SARS-CoV-2 in rhesus macaque and ferret challenge models
…, C Gilbride, DJ Harris, CMK Ho… - Communications …, 2021 - nature.com
Vaccines against SARS-CoV-2 are urgently required, but early development of vaccines
against SARS-CoV-1 resulted in enhanced disease after vaccination. Careful assessment of …
against SARS-CoV-1 resulted in enhanced disease after vaccination. Careful assessment of …
[HTML][HTML] Inhibition of IKKα by BAY61-3606 reveals IKKα-dependent histone H3 phosphorylation in human cytomegalovirus infected cells
CMK Ho, IZ Donovan-Banfield, L Tan, T Zhang… - PloS one, 2016 - journals.plos.org
Protein kinase inhibitors can be used as tools to identify proteins and pathways required for
virus replication. Using virus replication assays and western blotting we found that the widely …
virus replication. Using virus replication assays and western blotting we found that the widely …
[HTML][HTML] Identification of compounds with anti-human cytomegalovirus activity that inhibit production of IE2 proteins
Using a high throughput screening methodology we surveyed a collection of largely
uncharacterized validated or suspected kinase inhibitors for anti-human cytomegalovirus (HCMV) …
uncharacterized validated or suspected kinase inhibitors for anti-human cytomegalovirus (HCMV) …
Identification and characterization of bisbenzimide compounds that inhibit human cytomegalovirus replication
…, MRG Russell, CMK Ho… - Journal of General …, 2021 - microbiologyresearch.org
The shortcomings of current anti-human cytomegalovirus (HCMV) drugs has stimulated a
search for anti-HCMV compounds with novel targets. We screened collections of bioactive …
search for anti-HCMV compounds with novel targets. We screened collections of bioactive …
[HTML][HTML] Identification of lead anti-human cytomegalovirus compounds targeting MAP4K4 via machine learning analysis of kinase inhibitor screening data
BL Strang, CRM Asquith, HF Moshrif, CMK Ho… - PLoS …, 2018 - journals.plos.org
Chemogenomic approaches involving highly annotated compound sets and cell based high
throughput screening are emerging as a means to identify novel drug targets. We have …
throughput screening are emerging as a means to identify novel drug targets. We have …
Comparison of Rhesus and Cynomolgus macaques as an authentic model for COVID-19
…, J Gouriet, R Halkerston, DJ Harris, T Hender, CMK Ho… - bioRxiv, 2020 - biorxiv.org
A novel coronavirus, SARS-CoV-2, has been identified as the causative agent of the current
COVID-19 pandemic. Animal models, and in particular non-human primates, are essential to …
COVID-19 pandemic. Animal models, and in particular non-human primates, are essential to …