Prior SARS-CoV-2 infection rescues B and T cell responses to variants after first vaccine dose

CJ Reynolds, C Pade, JM Gibbons, DK Butler, AD Otter… - Science, 2021 - science.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine rollout has coincided
with the spread of variants of concern. We investigated whether single-dose vaccination, …

Randomized controlled trial of rituximab and cost‐effectiveness analysis in treating fatigue and oral dryness in primary Sjögren's syndrome

…, SP Ruddock, C Fernandez, C Reynolds… - Arthritis & …, 2017 - Wiley Online Library
Objective To investigate whether rituximab, an anti–B cell therapy, improves symptoms of
fatigue and oral dryness in patients with primary Sjögren's syndrome (SS). Methods We …

[HTML][HTML] COVID-19 vaccine-induced antibody and T-cell responses in immunosuppressed patients with inflammatory bowel disease after the third vaccine dose (VIP) …

…, Z Liu, DM Sandoval, C Reynolds… - The Lancet …, 2022 - thelancet.com
Background COVID-19 vaccine-induced antibody responses are reduced in patients with
inflammatory bowel disease (IBD) taking anti-TNF or tofacitinib after two vaccine doses. We …

[HTML][HTML] Blood transcriptional biomarkers of acute viral infection for detection of pre-symptomatic SARS-CoV-2 infection: a nested, case-control diagnostic accuracy …

…, L Rannigan, A Rapala, CJ Reynolds… - The Lancet …, 2021 - thelancet.com
Background We hypothesised that host-response biomarkers of viral infections might
contribute to early identification of individuals infected with SARS-CoV-2, which is critical to …

Immune boosting by B. 1.1. 529 (Omicron) depends on previous SARS-CoV-2 exposure

CJ Reynolds, C Pade, JM Gibbons, AD Otter, KM Lin… - Science, 2022 - science.org
The Omicron, or Pango lineage B.1.1.529, variant of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) carries multiple spike mutations with high transmissibility and …

[HTML][HTML] Comparative systematic review and meta-analysis of reactogenicity, immunogenicity and efficacy of vaccines against SARS-CoV-2

I McDonald, SM Murray, CJ Reynolds, DM Altmann… - npj Vaccines, 2021 - nature.com
As SARS-CoV-2 vaccines are deployed worldwide, a comparative evaluation is important to
underpin decision-making. We here report a systematic literature review and meta-analysis …

Objectification leads to depersonalization: The denial of mind and moral concern to objectified others

…, T Murnane, J Vaes, C Reynolds… - European Journal of …, 2010 - Wiley Online Library
Philosophers have argued that when people are objectified they are treated as if they lack
the mental states and moral status associated with personhood. These aspects of …

Discordant neutralizing antibody and T cell responses in asymptomatic and mild SARS-CoV-2 infection

CJ Reynolds, L Swadling, JM Gibbons, C Pade… - Science …, 2020 - science.org
Understanding the nature of immunity following mild/asymptomatic infection with SARS-CoV-2
is crucial to controlling the pandemic. We analyzed T cell and neutralizing antibody …

Heterologous infection and vaccination shapes immunity against SARS-CoV-2 variants

CJ Reynolds, JM Gibbons, C Pade, KM Lin… - Science, 2022 - science.org
The impact of the initial severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
infecting strain on downstream immunity to heterologous variants of concern (VOCs) is unknown…

Dietary supplementation with inulin-propionate ester or inulin improves insulin sensitivity in adults with overweight and obesity with distinct effects on the gut …

…, JI Serrano-Contreras, E Holmes, CJ Reynolds… - Gut, 2019 - gut.bmj.com
Objective To investigate the underlying mechanisms behind changes in glucose homeostasis
with delivery of propionate to the human colon by comprehensive and coordinated …