Evolutionary studies necessary to dissect diverse biological processes have been limited by
the lack of reverse genetic approaches in most organisms with sequenced genomes. We …

Distant-acting tissue-specific enhancers, which regulate gene expression, vastly outnumber
protein-coding genes in mammalian genomes, but the functional importance of this …

The evolution of body shape is thought to be tightly coupled to changes in regulatory
sequences, but specific molecular events associated with major morphological transitions in …

Exploitation of custom-designed nucleases to induce DNA double-strand breaks (DSBs) at
genomic locations of choice has transformed our ability to edit genomes, regardless of their …

Non-coding "ultraconserved" regions containing hundreds of consecutive bases of perfect
sequence conservation across mammalian genomes can function as distant-acting enhancers…

In many species, a dosage compensation complex (DCC) is targeted to X chromosomes of
one sex to equalize levels of X-gene products between males (1X) and females (2X). Here …

Whole-genome sequencing is identifying growing numbers of non-coding variants in human
disease studies, but the lack of accurate functional annotations prevents their interpretation. …

Embryogenesis requires epigenetic information that allows each cell to respond appropriately
to developmental cues. Histone modifications are core components of a cell’s epigenome, …

Epigenomic mapping of enhancer-associated chromatin modifications facilitates the genome-wide
discovery of tissue-specific enhancers in vivo. However, reliance on single chromatin …