Host sirtuin 1 regulates mycobacterial immunopathogenesis and represents a therapeutic target against tuberculosis

CY Cheng, NM Gutierrez, MB Marzuki, X Lu… - Science …, 2017 - science.org
Mycobacterium tuberculosis (Mtb) executes a plethora of immune-evasive mechanisms,
which contribute to its pathogenesis, limited efficacy of current therapy, and the emergence of …

[HTML][HTML] The extracellular calcium-sensing receptor in the intestine: evidence for regulation of colonic absorption, secretion, motility, and immunity

L Tang, CY Cheng, X Sun, AJ Pedicone… - Frontiers in …, 2016 - frontiersin.org
Different from other epithelia, the intestinal epithelium has the complex task of providing a
barrier impeding the entry of toxins, food antigens, and microbes, while at the same time …

[HTML][HTML] Histone acetylome-wide associations in immune cells from individuals with active Mycobacterium tuberculosis infection

…, J Poschmann, C Lim, CY Cheng… - Nature …, 2022 - nature.com
Host cell chromatin changes are thought to play an important role in the pathogenesis of
infectious diseases. Here we describe a histone acetylome-wide association study (HAWAS) of …

[HTML][HTML] mTORC2/Akt activation in adipocytes is required for adipose tissue inflammation in tuberculosis

…, CY Cheng, N Ketheesan, A Cullen, Y Tang… - …, 2019 - thelancet.com
Background Mycobacterium tuberculosis has co-evolved with the human host, adapting to
exploit the immune system for persistence and transmission. While immunity to tuberculosis (…

Metabolic energy sensors as targets for designing host-directed therapies for tuberculosis

CY Cheng, J Böhme, A Singhal - Journal of Leukocyte Biology, 2018 - academic.oup.com
A wealth of scientific and clinical evidence during the past few years has lent credence to the
idea that key components of the host immune effector mechanisms can be targeted to boost …

Author Correction: Histone acetylome-wide associations in immune cells from individuals with active Mycobacterium tuberculosis infection

…, J Poschmann, C Lim, CY Cheng… - Nature …, 2022 - ncbi.nlm.nih.gov
This paper was originally published under a standard Springer Nature license (© The Author
(s), under exclusive licence to Springer Nature America, Inc.). It is now available as an …

[HTML][HTML] Bumetanide increases Cl--dependent short-circuit current in late distal colon: Evidence for the presence of active electrogenic Cl- absorption

…, CY Cheng, HJ Binder, SA Rivkees, SX Cheng - Plos one, 2017 - journals.plos.org
Mammalian colonic epithelia consist of cells that are capable of both absorbing and secreting
Cl - . The present studies employing Ussing chamber technique identified two opposing …

Corrigendum: the extracellular calcium-sensing receptor in the intestine: evidence for regulation of colonic absorption, secretion, motility, and immunity

L Tang, CY Cheng, X Sun, AJ Pedicone… - Frontiers in …, 2016 - frontiersin.org
Cheng Catherine Y. Cheng 1 Xiangrong Sun Xiangrong Sun 1 Alexandra J. Pedicone
Alexandra J. Pedicone 1 Mansour Mohamadzadeh Mansour Mohamadzadeh 2 Sam X …

Histone acetylome-wide association study of tuberculosis

RCH del Rosario, J Poschmann, P Kumar, CY Cheng… - bioRxiv, 2019 - biorxiv.org
Host-cell chromatin changes are thought to play an important role in the pathogenesis of
infectious diseases. Here, we describe the first histone acetylome-wide association study (…

[HTML][HTML] Book Smart

CY Cheng - booksmartstreetsmart.com
After yet another hiatus from writing, I thought I would enter my second year of “blogging” by
sharing a piece of academic writing from my first year—one that I was (dare I say it) even …