User profiles for Catherine Z. Chen
 | Catherine Z ChenNational Center for Advancing Translational Sciences Verified email at mail.nih.gov Cited by 3857 |
[PDF][PDF] Human pluripotent stem cell-derived neural cells and brain organoids reveal SARS-CoV-2 neurotropism predominates in choroid plexus epithelium
Neurological complications are common in patients with COVID-19. Although severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), the causal pathogen of COVID-19, has …
respiratory syndrome coronavirus 2 (SARS-CoV-2), the causal pathogen of COVID-19, has …
Identification of SARS-CoV-2 3CL protease inhibitors by a quantitative high-throughput screening
W Zhu, M Xu, CZ Chen, H Guo, M Shen… - ACS pharmacology & …, 2020 - ACS Publications
The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) has emphasized the urgency to develop effective …
syndrome coronavirus 2 (SARS-CoV-2) has emphasized the urgency to develop effective …
Identification of 53 compounds that block Ebola virus-like particle entry via a repurposing screen of approved drugs
In light of the current outbreak of Ebola virus disease, there is an urgent need to develop
effective therapeutics to treat Ebola infection, and drug repurposing screening is a potentially …
effective therapeutics to treat Ebola infection, and drug repurposing screening is a potentially …
RNA-dependent RNA polymerase as a target for COVID-19 drug discovery
W Zhu, CZ Chen, K Gorshkov, M Xu… - … the Science of Drug …, 2020 - journals.sagepub.com
COVID-19 respiratory disease caused by the severe acute respiratory syndrome coronavirus-2
(SARS-CoV-2) has rapidly become a global health issue since it emerged in December …
(SARS-CoV-2) has rapidly become a global health issue since it emerged in December …
[PDF][PDF] Elp1p, the yeast homolog of the FD disease syndrome protein, negatively regulates exocytosis independently of transcriptional elongation
PB Rahl, CZ Chen, RN Collins - Molecular cell, 2005 - cell.com
The activation of Rab GTPases is a critical focal point of membrane trafficking events in
eukaryotic cells; however, the cellular mechanisms that spatially and temporally regulate this …
eukaryotic cells; however, the cellular mechanisms that spatially and temporally regulate this …
Identifying SARS-CoV-2 entry inhibitors through drug repurposing screens of SARS-S and MERS-S pseudotyped particles
CZ Chen, M Xu, M Pradhan, K Gorshkov… - ACS Pharmacology & …, 2020 - ACS Publications
While vaccine development will hopefully quell the global pandemic of COVID-19 caused
by SARS-CoV-2, small molecule drugs that can effectively control SARS-CoV-2 infection are …
by SARS-CoV-2, small molecule drugs that can effectively control SARS-CoV-2 infection are …
Dual prenylation is required for Rab protein localization and function
M Calero, CZ Chen, W Zhu, N Winand… - Molecular biology of …, 2003 - Am Soc Cell Biol
The majority of Rab proteins are posttranslationally modified with two geranylgeranyl lipid
moieties that enable their stable association with membranes. In this study, we present …
moieties that enable their stable association with membranes. In this study, we present …
[HTML][HTML] Drug repurposing screen for compounds inhibiting the cytopathic effect of SARS-CoV-2
CZ Chen, P Shinn, Z Itkin, RT Eastman… - Frontiers in …, 2021 - frontiersin.org
Drug repurposing is a rapid approach to identify therapeutics for the treatment of emerging
infectious diseases such as COVID-19. To address the urgent need for treatment options, we …
infectious diseases such as COVID-19. To address the urgent need for treatment options, we …
[HTML][HTML] Drug discovery strategies for SARS-CoV-2
Coronavirus disease 2019 (COVID-19) is a novel disease caused by the severe acute
respiratory syndrome coronavirus (SARS-CoV)-2 virus that was first detected in December of …
respiratory syndrome coronavirus (SARS-CoV)-2 virus that was first detected in December of …
The SARS-CoV-2 cytopathic effect is blocked by lysosome alkalizing small molecules
K Gorshkov, CZ Chen, R Bostwick… - ACS infectious …, 2020 - ACS Publications
Understanding the SARS-CoV-2 virus’ pathways of infection, virus–host–protein interactions,
and mechanisms of virus-induced cytopathic effects will greatly aid in the discovery and …
and mechanisms of virus-induced cytopathic effects will greatly aid in the discovery and …