A small proportion of breast cancer, in particular those cases arising at a young age, is due
to the inheritance of dominant susceptibility genes conferring a high risk of the disease. A …

Major depression is a debilitating psychiatric illness that is typically associated with low
mood and anhedonia. Depression has a heritable component that has remained difficult to …

Schizophrenia is a common disorder with high heritability and a 10-fold increase in risk to
siblings of probands. Replication has been inconsistent for reports of significant genetic …

A genome-wide association scan in individuals with Crohn's disease by the Wellcome Trust
Case Control Consortium detected strong association at four novel loci. We tested 37 SNPs …

A polygenic risk score (PRS) is a sum of trait-associated alleles across many genetic loci,
typically weighted by effect sizes estimated from a genome-wide association study. The …

Stroke has multiple etiologies, but the underlying genes and pathways are largely unknown.
We conducted a multiancestry genome-wide-association meta-analysis in 521,612 …

Huntington's disease (HD) is an inherited, progressive neurological disorder that is caused
by a CAG/polyglutamine repeat expansion and for which there is no effective therapy. Recent …

BACKGROUND &AIMS:: Mutations in the NOD2 gene are strongly associated with
susceptibility to Crohn's disease (CD). We analyzed a large cohort of European patients with …

Cannabis use has been reported to induce long-lasting psychotic disorders and a dose-response
relationship has been observed. We performed a systematic review of studies that …

Genome-wide association studies have shown unequivocally that common complex disorders
have a polygenic genetic architecture and have enabled researchers to identify genetic …