Human macrophages are specialised hosts for HIV-1, dengue virus, Leishmania and
Mycobacterium tuberculosis. Yet macrophage research is hampered by lack of appropriate cell …

An expanded hexanucleotide repeat in a noncoding region of the C9orf72 gene is a major
cause of amyotrophic lateral sclerosis (ALS), accounting for up to 40% of familial cases and 7…

Chronic granulomatous disease (CGD) is an inherited disorder of phagocytes in which
NADPH oxidase is defective in generating reactive oxygen species. In this study, we …

Background Mutations in LRRK2 are the most common cause of autosomal dominant Parkinson's
disease, and the relevance of LRRK2 to the sporadic form of the disease is becoming …

Despite the many advantages of Caenorhabditis elegans, biochemical approaches to study
tissue-specific gene expression in post-embryonic stages are challenging. Here, we report a …

Macrophages are components of the innate immune system with key roles in tissue inflammation
and repair. It is now evident that macrophages also support organogenesis, but few …

Non-neuronal cell types such as astrocytes can contribute to Parkinson's disease (PD)
pathology. The G2019S mutation in leucine-rich repeat kinase 2 (LRRK2) is one of the most …

Human induced pluripotent stem cells (iPSCs) and macrophages derived from them are
increasingly popular tools for research into both infectious and degenerative diseases. However…

Radical S‐adenosylmethionine (SAM) domain‐containing protein 2 (RSAD2; viperin) is a key
enzyme in innate immune responses that is highly expressed in response to viral infection …

The U1 small nuclear (sn)RNA (U1) is a multifunctional ncRNA, known for its pivotal role in
pre-mRNA splicing and regulation of RNA 3΄ end processing events. We recently …