The process of platelet production has so far been understood to be a 2-stage process:
megakaryocyte maturation from hematopoietic stem cells followed by proplatelet formation, with …

To coordinate iron supply with hemoglobin (Hb) synthesis, erythropoietin (EPO)-stimulated
erythroid precursors release erythroferrone (ERFE), a soluble protein that suppresses the …

Anemia affects 36% of pregnant women worldwide. Of those affected, around 40% is due to
iron deficiency (ID). Iron is an essential micronutrient involved in vital processes such as …

The principal morbidity and mortality in patients with essential thrombocythemia (ET) and
polycythemia rubra vera (PV) stems from thrombotic events. Most patients with ET/PV harbor a …

NBEAL2 encodes a multidomain scaffolding protein with a putative role in granule ontogeny
in human platelets. Mutations in NBEAL2 underlie gray platelet syndrome (GPS), a rare …

Somatic mutations in the endoplasmic reticulum chaperone calreticulin (CALR) are
detected in approximately 40% of patients with essential thrombocythemia (ET) and primary …

Upon activation, platelets release a powerful cocktail of soluble and vesicular signals,
collectively termed the "platelet releasate" (PR). Although several studies have used qualitative/…

Objective— Platelets are increasingly implicated in processes beyond hemostasis and
thrombosis, such as vascular remodeling. Members of the matrix metalloproteinase (MMP) family …

Wnt signaling is involved in numerous aspects of vertebrate development and homeostasis,
including the formation and function of blood cells. Here, we show that canonical and …

Polycythemia vera (PV) is a myeloproliferative neoplasm driven by activating mutations in
JAK2 that result in unrestrained erythrocyte production, increasing patients’ hematocrit and …