RNAi is a powerful tool for target identification and can lead to novel therapies for
pharmacologically intractable targets such as KRAS. RNAi therapy must combine potent siRNA …

Background KRAS mutations are present in up to 30% of lung adenocarcinoma cases and
are associated with poor survival. No effective targeted therapy against KRAS is currently …

The effects of reactive oxygen species on male fertility are governed by the oxidative paradox,
defined by a delicate balance between oxidative stress and antioxidant capacity. When …

Purpose: To investigate the effect of laser fiber stripping on stone fragmentation and laser
fiber power output. Materials and Methods: In a benchtop simulation of laser lithotripsy, 20 …

INTRODUCTION AND OBJECTIVE: Endoscopic combined intrarenal surgery (ECIRS), involving
percutaneous renal access and retrograde ureteroscopy, achieves high stone free rates …

Congenital bladder underdevelopment has detrimental genitourinary effects. We present a
male infant with declining renal function, recurrent urinary tract infections, and epididymo-…

Narcolepsy is a chronic sleep disorder characterized by excessive daytime sleepiness,
cataplexy, hypnagogic hallucinations, and sleep paralysis. Both sporadic and familial forms exist …

Infertility is defined as a couple’s inability to conceive following at least 12 months of unprotected
intercourse. Approximately 80% of couples are able to achieve pregnancy within the …

Objective To investigate the impact of renal function on the risk, severity, and management
of radiation cystitis in patients who underwent postoperative radiation therapy for prostate …

Percutaneous nephrolithotomy confers the highest radiation to the urologist’s hands compared
to other urologic procedures. This study compares radiation exposure to the surgeon’s …