The Polycomb group (PcG) of proteins form chromatin‐binding complexes with histone‐modifying
activity. The two main PcG repressive complexes studied ( PRC 1 and PRC 2) are …

Steroid hormones regulate gene expression by interaction of their receptors with hormone-responsive
elements on DNA or with other transcription factors, but they can also activate …

The human genome is segmented into topologically associating domains (TADs), but the role
of this conserved organization during transient changes in gene expression is not known. …

Transcription from the mouse mammary tumor virus (MMTV) promoter can be induced by
glucocorticoids or progestins. Progesterone treatment of cultured cells carrying an integrated …

Polycomb-group proteins are transcriptional repressors with essential roles in embryonic
development. Polycomb repressive complex 2 (PRC2) contains the methyltransferase activity …

In breast cancer cells, estrogens activate the Src/Erk pathway through an interaction of the
estrogen receptor alpha (ERα) with the SH2 domain of c-Src. Progestins have been reported …

How genes are regulated in the context of chromatin is a central question of biology. Steroid
hormones control gene expression via interaction of their receptors with target sequences …

The unicellular ancestor of animals had a complex repertoire of genes linked to multicellular
processes. This suggests that changes in the regulatory genome, rather than in gene …

Elucidating the global function of a transcription factor implies the identification of its target
genes and genomic binding sites. The role of chromatin in this context is unclear, but the …

In embryonic stem cells (ESCs), developmental gene promoters are characterized by their
bivalent chromatin state, with simultaneous modification by MLL2 and Polycomb complexes. …