Broad neutralization of SARS-related viruses by human monoclonal antibodies

…, E Laudermilch, C Florez, JM Fels, CM O'Brien… - Science, 2020 - science.org
Broadly protective vaccines against known and preemergent human coronaviruses (HCoVs)
are urgently needed. To gain a deeper understanding of cross-neutralizing antibody …

Broad and potent activity against SARS-like viruses by an engineered human monoclonal antibody

…, TJ Yockachonis, AS Herbert, MB Battles, CM O'Brien… - Science, 2021 - science.org
The recurrent zoonotic spillover of coronaviruses (CoVs) into the human population
underscores the need for broadly active countermeasures. We employed a directed evolution …

Structural and mechanistic basis of neutralization by a pan-hantavirus protective antibody

…, C Florez, LC Polanco, CM O'Brien… - Science translational …, 2023 - science.org
Emerging rodent-borne hantaviruses cause severe diseases in humans with no approved
vaccines or therapeutics. We recently isolated a monoclonal broadly neutralizing antibody (…

Human antibody recognizing a quaternary epitope in the Puumala virus glycoprotein provides broad protection against orthohantaviruses

…, J Wigren-Byström, LC Polanco, CM O'Brien… - Science translational …, 2022 - science.org
The rodent-borne hantavirus Puumala virus (PUUV) and related agents cause hemorrhagic
fever with renal syndrome (HFRS) in humans. Other hantaviruses, including Andes virus (…

A combination of receptor-binding domain and N-terminal domain neutralizing antibodies limits the generation of SARS-CoV-2 spike neutralization-escape mutants

…, ME Dieterle, AZ Wec, CM O'brien, M Sakharkar… - Mbio, 2021 - Am Soc Microbiol
Most known SARS-CoV-2 neutralizing antibodies (nAbs), including those approved by the
FDA for emergency use, inhibit viral infection by targeting the receptor-binding domain (RBD) …

Optimization of Isothiazolo[4,3-b]pyridine-Based Inhibitors of Cyclin G Associated Kinase (GAK) with Broad-Spectrum Antiviral Activity

…, R Barouch-Bentov, LI Prugar, CM O'Brien… - Journal of medicinal …, 2018 - ACS Publications
There is an urgent need for strategies to combat dengue and other emerging viral infections.
We reported that cyclin G-associated kinase (GAK), a cellular regulator of the clathrin-…

[HTML][HTML] Broad sarbecovirus neutralizing antibodies define a key site of vulnerability on the SARS-CoV-2 spike protein

…, E Laudermilch, C Florez, JM Fels, CM O'Brien… - BioRxiv, 2020 - ncbi.nlm.nih.gov
Broadly protective vaccines against known and pre-emergent coronaviruses are urgently
needed. Critical to their development is a deeper understanding of cross-neutralizing antibody …

[HTML][HTML] An engineered antibody with broad protective efficacy in murine models of SARS and COVID-19

…, TJ Yockachonis, AS Herbert, MB Battles, CM O'Brien… - BioRxiv, 2020 - ncbi.nlm.nih.gov
The recurrent zoonotic spillover of coronaviruses (CoVs) into the human population underscores
the need for broadly active countermeasures. Here, we employed a directed evolution …

A combination of RBD and NTD neutralizing antibodies limits the generation of SARS-CoV-2 spike neutralization-escape mutants

…, ME Dieterle, AZ Wec, CM O'Brien, M Sakharkar… - bioRxiv, 2021 - biorxiv.org
Most known SARS-CoV-2 neutralizing antibodies (nAbs), including those approved by the
FDA for emergency use, inhibit viral infection by targeting the receptor-binding domain (RBD) …

Animal Model Prescreening: Pre-exposure to SARS-CoV-2 impacts responses in the NHP model

…, TL Clements, CJ Shoemaker, AI Kuehne, CM O'Brien… - bioRxiv, 2020 - biorxiv.org
COVID-19 presents herculean challenges to research and scientific communities for producing
diagnostic and treatment solutions. Any return to normalcy requires rapid development of …