Mutations in DJ-1, PINK1 (PTEN-induced putative kinase 1) and parkin all cause recessive
parkinsonism in humans, but the relationships between these genes are not clearly defined. …

Alzheimer's disease (AD) is the leading cause of dementia, and because the primary risk
factor for AD is old age, the prevalence of the disease is increasing dramatically with ageing …

The risk of dementia and Alzheimer's disease (AD) probably results from an interaction
between genetic and environmental factors. The aim of this study was to investigate the effects …

Alzheimer’s disease (AD) is the most common form of dementia in the elderly, with increasing
prevalence and no disease-modifying treatment available yet. A remarkable amount of …

In contrast to their parent molecule cholesterol, two of its side-chain oxidized metabolites
are able to cross the blood–brain barrier. There is a concentration-driven flux of 24S-…

Strong evidence indicates oxidative stress in the pathogenesis of Alzheimer's disease (AD).
Amyloid β (Aβ) has been implicated in both oxidative stress mechanisms and in neuronal …

Peering into the field of Alzheimer’s disease (AD), the outsider realizes that many of the
therapeutic strategies tested (in animal models) have been successful. One also may notice that …

An early diagnosis of Alzheimer’s disease (AD) and other types of dementia-causing disorders
is vital in order to achieve effective treatments. Fortunately, in the recent years the search …

Alzheimer’s disease (AD) is the most prevalent form of dementia with an estimated
worldwide prevalence of over 30 million people, and its incidence is expected to increase …

Introduction Our objective was to compare the levels of three synaptic proteins involved in
different steps of the synaptic transmission: Rab3A, SNAP25, and neurogranin, in three …