[HTML][HTML] The integrated stress response is tumorigenic and constitutes a therapeutic liability in KRAS-driven lung cancer
…, J Krishnamoorthy, V van Hoef, C Darini… - Nature …, 2021 - nature.com
The integrated stress response (ISR) is an essential stress-support pathway increasingly
recognized as a determinant of tumorigenesis. Here we demonstrate that ISR is pivotal in lung …
recognized as a determinant of tumorigenesis. Here we demonstrate that ISR is pivotal in lung …
[HTML][HTML] An integrated stress response via PKR suppresses HER2+ cancers and improves trastuzumab therapy
C Darini, N Ghaddar, C Chabot, G Assaker… - Nature …, 2019 - nature.com
Trastuzumab is integral to HER2+ cancer treatment, but its therapeutic index is narrowed by
the development of resistance. Phosphorylation of the translation initiation factor eIF2α (…
the development of resistance. Phosphorylation of the translation initiation factor eIF2α (…
[HTML][HTML] Breast cancer mammospheres secrete Adrenomedullin to induce lipolysis and browning of adjacent adipocytes
M Paré, CY Darini, X Yao, B Chignon-Sicard, S Rekima… - BMC cancer, 2020 - Springer
Background Cancer cells cooperate with cells that compose their environment to promote
tumor growth and invasion. Among them, adipocytes provide lipids used as a source of energy …
tumor growth and invasion. Among them, adipocytes provide lipids used as a source of energy …
Lopinavir co-induces insulin resistance and ER stress in human adipocytes
M Djedaini, P Peraldi, MD Drici, C Darini… - Biochemical and …, 2009 - Elsevier
HIV-protease inhibitors (PIs) markedly decreased mortality of HIV-infected patients. However,
their use has been associated with occurence of metabolic abnormalities the causes of …
their use has been associated with occurence of metabolic abnormalities the causes of …
STAT1 Promotes KRAS Colon Tumor Growth and Susceptibility to Pharmacological Inhibition of Translation Initiation Factor eIF4A
S Wang, C Darini, L Désaubry, AE Koromilas - Molecular cancer therapeutics, 2016 - AACR
The transcription factor STAT1 displays antitumor functions for certain forms of cancer via
immunoregulatory and cell-autonomous pathways. Paradoxically, STAT1 can promote the …
immunoregulatory and cell-autonomous pathways. Paradoxically, STAT1 can promote the …
[HTML][HTML] Downregulation of PERK activity and eIF2α serine 51 phosphorylation by mTOR complex 1 elicits pro-oxidant and pro-death effects in tuberous sclerosis …
…, J Gupta, N Ghaddar, S Wang, C Darini… - Cell Death & …, 2018 - nature.com
Oxidative stress determines cell fate through several mechanisms, among which regulation
of mRNA translation by the phosphorylation of the alpha (α) subunit of the translation …
of mRNA translation by the phosphorylation of the alpha (α) subunit of the translation …
[HTML][HTML] Abstract B086: Targeting ATR to overcome Carboplatin resistance in triple-negative breast cancer patient-derived models
J Guay, C Chabot, C Darini, M Buchanan… - NaN, 2023 - citedrive.com
… Juliet Guay, Catherine Chabot, Cédric Darini, Marguerite Buchanan, Adriana Aguilar-Mahecha,
Tim Kong, Connie Yang, Mark Basik, Sidong Huang … Citation Format: Juliet Guay …
Tim Kong, Connie Yang, Mark Basik, Sidong Huang … Citation Format: Juliet Guay …
Abstract A045: EZH2 inhibition re-sensitizes drug resistant triple-negative breast cancer PDX models to Eribulin
K Bozek, C Darini, C Lan, M Buchanan, C Chabot… - Molecular Cancer …, 2023 - AACR
Background: Triple negative breast cancer (TNBC) is the most aggressive subtype of breast
cancer predominantly affecting younger women. The mainstay of treatment is chemotherapy, …
cancer predominantly affecting younger women. The mainstay of treatment is chemotherapy, …
The use of conditionally reprogrammed cells for high throughput screening for novel drug combinations to treat drug resistant triple negative breast cancers
…, C Chabot, N Santos-Martinez, C Darini… - Cancer Research, 2020 - AACR
Triple negative breast cancer (TNBC) is the most aggressive form of breast cancer, with
prognosis tightly dependent on its responsiveness to cytotoxic chemotherapy. Indeed, …
prognosis tightly dependent on its responsiveness to cytotoxic chemotherapy. Indeed, …
An evolving cancer instigates clonally unrelated neighboring cells to form distant metastases
J Dong, C Darini, F Kabeer, S Dendievel, J Min… - bioRxiv, 2016 - biorxiv.org
Based on the clonal evolution theory of cancer formation, a single cell within a tissue gains
a cancer-driving mutation and thus a growth advantage. From this expanded cellular mass, …
a cancer-driving mutation and thus a growth advantage. From this expanded cellular mass, …